Plasmalogen deficiency is associated with several alterations of cortex fatty acid species that are not prevented by AKG supplementation. A) Saturated fatty acids profile. Plasmalogen deficiency was mainly associated with an increase in stearic acid (C18:0). AKG maternal supplementation did not affect any of the saturated chains concentrations. B) Monounsaturated fatty acids profile. Plasmalogen deficiency was associated with small but significant increases in several monounsaturated chains, especially in 18:1n−9 and 18:1n−7, that were partially restored by AKG maternal supplementation as they were no longer different when compared to WT. C) n−6 polyunsaturated fatty acids (PUFA) profile. Plasmalogen deficiency was especially associated with a significant increase in C20:4n−6 (ARA) levels, that were not restored through maternal supplementation with AKG. D) n−3 PUFA profile. Plasmalogen deficiency was associated with a strong and significant decrease in C22:6n−3 (DHA) levels, that was not restored through maternal supplementation with AKG. E) Plasmalogen deficiency was associated with a significant increase in total cortex n−6 PUFA, that was not modified by AKG maternal supplementation. F) Plasmalogen deficiency was associated with a significant decrease in total cortex n−3 PUFA, that was not modified by AKG maternal supplementation. G) Plasmalogen deficiency was associated with a strong and significant increase of the n−6:n−3 PUFA ratio in the brain cortex. AKG nutritional supplementation of lactating mothers had no effect on the n−6:n−3 PUFAs ratio of the pups’ cortices. * p <0.05; ** p <0.01; ***p <0.001. n = 2–8. One-way ANOVA with post-hoc Tukey’s multiple comparisons test. FAMEs: Fatty acid methyl esters.