An overview of phospholipids turnover, arachidonic acid, and eicosanoid signaling in schizophrenia symptomatology (adapted from Skosnik and Yao, 2003). Abbreviations: AODS, antioxidant defense system; NT, neurotransmitters; RO, reactive oxygen species; apoD, apolipoprotein D; PLA₂, phospholipase A₂; PLC, phospholipase C; LOX, lipooxygenase; AA, arachidonic acid; DAG, diacylglycerol; COX, cyclooxygenase; 2-AG, 2-arachidonoyl glycerol; GAP, growth-associated protein; PKC, phosphokinase C; PGG₂. prostaglandin G₂; PGH₂, prostaglandin H₂; PGD₂, prostaglandin D₂; CB, cannabinoid.