Brain nutritional lipids sensing and the central regulation of energy balance. We therefore propose that the central availability of TG and FA differe, that these lipid species influence neural circuit function through separate mechanisms, and that they have opposing effects on food-seeking behaviour. Although FA may principally act in the hypothalamus and function to increase food intake in response to a fast, TG sensing may depend on local hydrolysis by LpL in the mesolimbic pathway where they decrease the rewarding or motivational properties of food. Amy, amygdala; ARC, arcuate nucleus; Cpu, caudate putamen; DMH, dorsomedial hypothalmaus; HP, hippocampus; LH, lateral nucleus; LPL, Lipoprotein lipase; Nacc, nucleus accumbens; NTS, nucleus tractus solitarius; PFC, prefrontal cortex; PVN, para-venticular nucleus; SN, substantia nigra; VMH, ventromedial hypothalamus; VTA, ventral tegmental area.