CLA et syndrome lipoatrophique chez la souris

¹ Physiologie de la nutrition, Ecole nationale supérieure de biologie, appliquée à la nutrition et à l’alimentation (ENSBANA), UMR 5170 CNRS/INRA/UB, 1, Esplanade Erasme, 21000 Dijon, France
² U465 Inserm, Centre de recherche des Cordeliers Université Pierre et Marie Curie F-75005 Paris

^* pbesnard@u-bourgogne.fr

Abstract

Conjugated linoleic acid (CLA) refers to a class of positional and geometric dienoic isomers of linoleic acid. Chronic dietary supplementation with a commercial mixture containing c9,t11-CLA and t10,c12-CLA in equimolar quantity leads to a drop in fat mass in various species. The t10,c12-CLA isomer is responsible for this anti-obesity effect. The reduction of fat mass is especially dramatic in the mouse, in which it is associated with a severe hyperinsulinemia, an insulin resistance and a massive liver steatosis. The origin of these adverse side effects and the putative chronology of events leading to CLA-mediated lipoatrophic syndrome are presented and discussed in this review.