Early life exposure to polyunsaturated fatty acids and psychomotor development in children from the EDEN mother-child cohort | OCL

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Table 2

Associations of dietary LA intake, n-6/n-3 and LA/ALA ratios during pregnancy with child’s psychomotor development at 2 and 3 years in the EDEN study, according to child’s breastfeeding status.

	Motor-2		CDI-2		ASQ-3

	β ± SE	P	β ± SE	P	β ± SE	P

All children	n = 1203		n = 1215		n = 1061
LA, g/d	−0.03 ± 0.02	0.11	−0.04 ± 0.26	0.9	−0.47 ± 0.28	0.10
Total n6/n3 ratio	−0.06 ± 0.03	0.04	−0.26 ± 0.34	0.4	−0.89 ± 0.36	0.01
LA/ALA ratio	−0.04 ± 0.02	0.07	−0.31 ± 0.29	0.3	−0.85 ± 0.31	0.005
Breastfed children	n = 896		n = 905		n = 790
LA, g/d	−0.02 ± 0.02	0.4	0.24 ± 0.30	0.4	−0.22 ± 0.31	0.5
Total n6/n3 ratio	−0.05 ± 0.03	0.2	0.38 ± 0.34	0.3	−0.65 ± 0.40	0.11
LA/ALA ratio	−0.03 ± 0.03	0.2	0.33 ± 0.34	0.3	−0.57 ± 0.35	0.10
Never breastfed children	n = 307		n = 310		n = 271
LA, g/d	−0.09 ± 0.05	0.07	−1.23 ± 0.58	0.03	−1.38 ± 0.70	0.05
Total n6/n3 ratio	−0.08 ± 0.06	0.2	−2.07 ± 0.65	0.002	−1.33 ± 0.79	0.09
LA/ALA ratio	−0.06 ± 0.05	0.2	−1.89 ± 0.54	0.0005	−1.38 ± 0.64	0.03

Models were adjusted for study centre, child’s sex and age at assessment, duration of gestation, maternal age, primiparity, maternal pre-pregnancy obesity, maternal total energy intake, smoking status, alcohol consumption, parental education level, household income, child’s caregiver at 2 years, frequency of mother-child activities. Models with ASQ were additionally adjusted for duration of preschool attendance at 3 years. SE, standard error; LA, linoleic acid; ALA, alpha-linolenic acid; Motor-2, motor development at 2 years; CDI-2, communicative development inventory at 2 years; ASQ-3, ages and stages questionnaire at 3 years.

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