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Table 2

Fatty acid composition of cardiac phospholipids.

Control HF ZL ZDF

SFA 38.8 ± 0.2 43.3 ± 0.9* 35.9 ± 0.8 44.7 ± 1.1*
MUFA 8.9 ± 0.2 7.1 ± 0.1* 9.8 ± 0.4 6.2 ± 0.2*
PUFA 52.4 ± 0.1 49.8 ± 0.8* 54.2 ± 0.6 49.1 ± 1.2*
C18:2 n-6 26.5 ± 1.3 20.7 ± 1.0* 32.9 ± 1.8 15.7 ± 2.6*
C20:4 n-6 17.0 ± 0.3 19.9 ± 0.8* 16.0 ± 0.8 23.6 ± 1.6*
C22:4 n-6 0.2 ± 0.1 0.5 ± 0.1* 0.4 ± 0.1 0.4 ± 0.1
C22:5 n-6 0.2 ± 0.1 0.5 ± 0.1* 0.3 ± 0.1 0.4 ± 0.1
n-6 PUFA 44.4 ± 1.0 41.9 ± 0.3* 50.2 ± 0.9 41.2 ± 1.3*
C20:5 n-3 0.12 ± 0.01 0.10 ± 0.02 0.10 ± 0.01 0.08 ± 0.06
C22:5 n-3 0.7 ± 0.1 1.8 ± 0.1* 0.5 ± 0.1 1.3 ± 0.1*
C22:6 n-3 5.5 ± 0.2 5.4 ± 0.4 3.3 ± 0.4 6.5 ± 0.5*
n-3 PUFA 6.4 ± 0.2 7.1 ± 0.5 4.0 ± 0.5 7.9 ± 0.6*
n-6/n-3 7.0 ± 0.1 5.9 ± 0.4 13.5 ± 1.7 5.4 ± 0.5*
EPA/AA 6.8 ± 0.8 5.0 ± 1.1 6.1 ± 0.5 3.6 ± 0.5*
EPA+DHA 5.7 ± 0.2 5.5 ± 0.4 3.4 ± 0.4 6.6 ± 0.6*
C18:0/C16:0 1.6 ± 0.1 2.5 ± 0.1* 1.6 ± 0.1 1.9 ± 0.1*
C18:1n-7/C16:1n-7 10.9 ± 1.6 22.0 ± 3.0* 10.4 ± 0.5 9.4 ± 0.5
C20:2n-6/C18:2n-6 3.9 ± 0.1 10.3 ± 0.7* 5.3 ± 0.7 12.8 ± 3.2*
C22:4n-6/C20:4n-6 1.4 ± 0.1 2.4 ± 0.1* 2.4 ± 0.1 1.6 ± 0.1*
C22:5n-3/C20:5n-3 7.2 ± 1.7 25.4 ± 5.6* 5.1 ± 0.4 15.6 ± 1.6*
C16:1n-7/C16:0 4.0 ± 0.6 1.2 ± 0.1* 4.4 ± 0.1 2.7 ± 0.1*
C18:3n-6/C18:2n-6 7.8 ± 0.5 3.7 ± 0.8 *
C20:4n-6/C20:3n-6 62.7 ± 5.6 33.4 ± 2.7* 41.6 ± 4.1 25.2 ± 4.7*

The number of experiments was 10 per group. The EPA to AA ratio must be multiplied by 10-3. The C22:4 n-6/20:4 n-6 and C16:1 n-7/C16:0 ratios must be multiplied by 10-2. The C20:2 n-6/C18:2 n-6 and C18:3 n-6/C18:2 n-6 ratios must be multiplied by 10-3 and 10-4, respectively. HF: high fat fed rats; ZL: Zucker lean rats; ZDF: Zucker Diabetic Fatty rats; SFA: sum of saturated fatty acids; MUFA sum of monounsaturated fatty acids; PUFA: sum of polyunsaturated fatty acids; n-6/n-3: n-6/n-3 PUFA ratio; EPA: eicosapentaenoic acid or C20:5 n-3, AA: arachidonic acid or C20:4 n-6; DHA: docosahexaeboic acid or C22:6 n-3; -: missing data; *: significantly different between HF and control rats or ZL and ZDF animals.

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