Neuroinflammation, n-3 PUFAs and aging. Aging is characterized by a chronic low grade inflammatory state with a microglial activation and a higher expression of proinflammatory cytokines to the detriment of anti-inflammatory factors. This state is called inflammaging at the periphery and in the brain. Inflammaging could be linked to the decrease in brain n-3 PUFA and involved in altered well-being measured in elderly.