Evolution of predicted mean BVRT score for three typical levels of plasma EPA proportion according to depressive symptoms and ApoE4 carrier status, estimated in a multivariate linear mixed model in participants from the Bordeaux Sample of the Three-City Study non demented at baseline (1999-2006) (N=1,130), published in (Samieri, Feart et al, 2010). ApoE4 carriers (at least one -ε4 allele) were noted as ApoE4 + and ApoE4 non carriers as ApoE4. Participants with high depressive symptoms were noted as dep + and those with low depressive symptoms as dep –. Predicted mean evolution of cognitive scores over time were represented for men with average age (74 y), body mass index (26.4 kg/m²), number of drugs regularly consumed (4), plasma vitamin E (15.8 mmol/L) and triglycerides (1.3 mmol/L), and who had a low level of education, were married, non-smokers, who did not consume alcohol or use antidepressants, who had no history of cardiovascular disease, no diabetes and no recent weight loss >3 kg. The three typical values of plasma EPA were chosen as: overall mean – 1 SD; overall mean; overall mean + 1 SD. In each group, Beta coefficients and their p-value were given for EPA x Time term (corresponding to the variation in slope associated with each increase of 1 standard deviation of plasma EPA). Abbreviations: BVRT: Benton Visual Retention Test; EPA: eicosapentaenoic acid.