Métabolomique, métabonomique et les préoccupations en matière de sécurité alimentaire et de protection de la santé des consommateurs^*

¹ UMR1089 – Xénobiotiques, INRA-ENVT, Toulouse
² UR66 – Pharmacologie-Toxicologie, INRA, Toulouse

^* aparis@toulouse.inra.fr

Abstract

Metabonomics is a recent method devoted to the high throughput metabolic phenotyping of biological systems usable to perform a deep functional exploration when physiological, toxicological, genetic or nutritional perturbations are considered. From some pivotal examples, will be illustrated some concepts such as “metabolic disruptions” or “set of metabolic biomarkers”, which are routinely used in toxicological studies of living systems with the final aim to (i) better characterize some homeostatic rules involved in response to toxic insults and (ii) to better know prediction rules usable to classify unknown individuals given the knowledge of dedicated reference data set. Hereafter are presented illustrative cases concerning the use of steroidal anabolics in growing cattle, the characterization of secondary metabolites present in a plant which is toxic for equine species, or the description of some metabolic effects induced by an endocrine disruptor widely used in plastic industry.