| Issue |
OCL
Volume 15, Number 5, Septembre-Octobre 2008
|
|
|---|---|---|
| Page(s) | 300 - 304 | |
| Section | Qualité – Sécurité Alimentaire | |
| DOI | https://doi.org/10.1051/ocl.2008.0222 | |
| Published online | 15 September 2008 | |
Métabolomique, métabonomique et les préoccupations en matière de sécurité alimentaire et de protection de la santé des consommateurs*
1
UMR1089 – Xénobiotiques, INRA-ENVT, Toulouse
2
UR66 – Pharmacologie-Toxicologie, INRA, Toulouse
Abstract
Metabonomics is a recent method devoted to the high throughput metabolic phenotyping of biological systems usable to perform a deep functional exploration when physiological, toxicological, genetic or nutritional perturbations are considered. From some pivotal examples, will be illustrated some concepts such as “metabolic disruptions” or “set of metabolic biomarkers”, which are routinely used in toxicological studies of living systems with the final aim to (i) better characterize some homeostatic rules involved in response to toxic insults and (ii) to better know prediction rules usable to classify unknown individuals given the knowledge of dedicated reference data set. Hereafter are presented illustrative cases concerning the use of steroidal anabolics in growing cattle, the characterization of secondary metabolites present in a plant which is toxic for equine species, or the description of some metabolic effects induced by an endocrine disruptor widely used in plastic industry.
Key words: metabonomics / food safety / metabolic disruptions
Conférence issue de la séance du 18 juin 2008 de l’Académie d’Agriculture. Voir la présentation à l’adresse suivante : www.academie-agriculture.fr/detail-seance_37.html.
© John Libbey Eurotext 2008
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