The intake of long chain omega 3 fatty acids through fish versus capsules results in greater increments of their plasma levels

¹ University of Milan, Department of Pharmacological Sciences
² Department of Pharmacological Sciences, Via Balzaretti 9, 20133 Milan, Italy + 39.0250318309 + 39.0250318284

^* claudio.galli@unimi.it

Abstract

Omega 3 fatty acids from fish appear to be more cardioprotective than equivalent amounts provided as capsules. We gave volunteers, for six weeks, either 100 g\\day of salmon, providing 383 mg of EPA and 544 mg of DHA or one or three capsules of fish oil\\day, providing 150 mg of EPA and 106 mg of DHA or 450 mg of EPA and 318 mg of DHA. We also re-evaluated data from a previous study carried out with the same design. Marked increments in plasma EPA and DHA concentrations (μg\\mg total lipid) and percentages of total fatty acids were recorded at the end of either treatment. Such increments were linearly and significantly correlated with the dose after capsule administration. Notably, increments in plasma EPA and DHA concentration after salmon intake were significantly higher than after administration of capsules. In fact, the same increments would be obtained with at least two- and nine-fold higher doses of EPA and DHA, respectively, if administered with capsules rather than salmon. In turn, we provide experimental evidence that omega 3 fatty acids from fish are more effectively incorporated into plasma lipids than when administered as capsules and that increments in plasma concentrations of EPA and DHA given as capsules are linearly correlated with their intakes.