Open Access
Volume 24, Number 2, March–April 2017
Article Number D203
Number of page(s) 12
Section Bioavailability and tissue-targeting dietary lipids: new approaches to their formulation? / Biodisponibilité et ciblage tissulaire des lipides alimentaires : nouvelles stratégies pour la formulation ?
Published online 06 April 2017
  • Amar J, Burcelin R, Ruidavets JB, et al. 2008. Energy intake is associated with endotoxemia in apparently healthy men. Am J Clin Nutr 87 (5): 1219–1223. [CrossRef] [PubMed] [Google Scholar]
  • Armand M, Pasquier B, Andre M, et al. 1999. Digestion and absorption of 2 fat emulsions with different droplet sizes in the human digestive tract. Am J Clin Nutr 70 (6): 1096–1106. [CrossRef] [PubMed] [Google Scholar]
  • Awada M, Meynier A, Soulage CO, et al. 2012. Dietary oxidized n-3 PUFA induce oxidative stress and inflammation: role of intestinal absorption of 4-HHE and reactivity in intestinal cells. J Lipid Res 53 (10): 2069–2080. [CrossRef] [PubMed] [Google Scholar]
  • Awada M, Soulage CO, Meynier A, et al. 2013. n-3 PUFA added to high-fat diets affect differently adiposity and inflammation when carried by phospholipids or triacylglycerols in mice. Nutr Metab (Lond) 10 (1): 23. [CrossRef] [PubMed] [Google Scholar]
  • Bazil V, Strominger JL. 1991. Shedding as a mechanism of down-modulation of CD14 on stimulated human monocytes. J Immunol 147 (5): 1567–1574. [Google Scholar]
  • Bourlieu C, Michalski MC. 2015. Structure-function relationship of the milk fat globule. Curr Opin Clin Nutr Metab Care 18 (2): 118–127. [CrossRef] [PubMed] [Google Scholar]
  • Bunea R, El Farrah K, Deutsch L. 2004. Evaluation of the effects of Neptune Krill Oil on the clinical course of hyperlipidemia. Altern Med Rev 9 (4): 420–428. [PubMed] [Google Scholar]
  • Burling H, Nilsson A, Ohlsson L. 2009. Milk phospholipids, a new ingredient for formulation of functional foods with bioactivity. Inform 20 (8): 494–496. [Google Scholar]
  • Cani PD, Amar J, Iglesias MA, et al. 2007. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 56 (7): 1761–1772. [CrossRef] [PubMed] [Google Scholar]
  • Cani PD, Bibiloni R, Knauf C, et al. 2008. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes 57 (6): 1470–1481. [CrossRef] [PubMed] [Google Scholar]
  • Cansell M, Nacka F, Combe N. 2003. Marine lipid-based liposomes increase in vivo FA bioavailability. Lipids 38 (5): 551–559. [CrossRef] [PubMed] [Google Scholar]
  • Cansell M, Moussaoui N, Petit AP, et al. 2006. Feeding rats with liposomes or fish oil differently affects their lipid metabolism. Eur J Lipid Sci Technol 108: 459–467. [CrossRef] [Google Scholar]
  • Castro-Gomez P, Garcia-Serrano A, Visioli F, et al. 2015. Relevance of dietary glycerophospholipids and sphingolipids to human health. Prostaglandins Leukot Essent Fatty Acids 101: 41–51. [CrossRef] [PubMed] [Google Scholar]
  • Chassaing B, Koren O, Goodrich JK, et al. 2015. Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome. Nature 519 (7541): 92–96. [CrossRef] [PubMed] [Google Scholar]
  • Clemente-Postigo M, Queipo-Ortuno MI, Murri M, et al. 2012. Endotoxin increase after fat overload is related to postprandial hypertriglyceridemia in morbidly obese patients. J Lipid Res 53 (5): 973–978. [CrossRef] [PubMed] [Google Scholar]
  • Cohn J, Tandy S, Wat E, et al. 2009. Dietary milk phospholipid as a cardiovascular nutraceutical. Atheroscler Suppl 10: 2. [CrossRef] [Google Scholar]
  • Couëdelo L, Boue-Vaysse C, Fonseca L, et al. 2011. Lymphatic absorption of alpha-linolenic acid in rats fed flaxseed oil-based emulsion. Br J Nutr 105 (7): 1026–1035. [CrossRef] [PubMed] [Google Scholar]
  • Coudelo L, Amara S, Lecomte M, et al. 2015. Impact of various emulsifiers on ALA bioavailability and chylomicron synthesis through changes in gastrointestinal lipolysis. Food Funct 6 (5): 1726–1735. [CrossRef] [PubMed] [Google Scholar]
  • Creely SJ, McTernan PG, Kusminski CM, et al. 2007. Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes. Am J Physiol Endocrinol Metab 292 (3): E740–E747. [CrossRef] [PubMed] [Google Scholar]
  • Deopurkar R, Ghanim H, Friedman J, et al. 2010. Differential effects of cream, glucose, and orange juice on inflammation, endotoxin, and the expression of Toll-like receptor-4 and suppressor of cytokine signaling-3. Diabetes Care 33 (5): 991–997. [CrossRef] [PubMed] [Google Scholar]
  • Dey TK, Ghosh S, Ghosh M, et al. 2012. Comparative study of gastrointestinal absorption of EPA & DHA rich fish oil from nano and conventional emulsion formulation in rats. Food Res Int 49 (1): 72–79. [CrossRef] [Google Scholar]
  • Eichbaum EB, Harris HW, Kane JP, et al. 1991. Chylomicrons can inhibit endotoxin activity in vitro. J Surg Res 51 (5): 413–416. [CrossRef] [PubMed] [Google Scholar]
  • Erridge C, Attina T, Spickett CM, et al. 2007. A high-fat meal induces low-grade endotoxemia: evidence of a novel mechanism of postprandial inflammation. Am J Clin Nutr 86 (5): 1286–1292. [CrossRef] [PubMed] [Google Scholar]
  • Fernandez-Real JM, Perez del Pulgar S, Luche E, et al. 2011. CD14 modulates inflammation-driven insulin resistance. Diabetes 60 (8): 2179–2186. [CrossRef] [PubMed] [Google Scholar]
  • Gallay P, Barras C, Tobias PS, et al. 1994. Lipopolysaccharide (LPS)-binding protein in human serum determines the tumor necrosis factor response of monocytes to LPS. J Infect Dis 170 (5): 1319–1322. [CrossRef] [PubMed] [Google Scholar]
  • Garaiova I, Guschina I, Plummer SF, et al. 2007. A randomised cross-over trial in healthy adults indicating improved absorption of omega-3 fatty acids by pre-emulsification. Nutr J 6 (1): 4. [CrossRef] [PubMed] [Google Scholar]
  • Gautier T, Klein A, et al. 2008. Effect of plasma phospholipid transfer protein deficiency on lethal endotoxemia in mice. J Biol Chem 283 (27): 18702–18710. [CrossRef] [PubMed] [Google Scholar]
  • Genot C, Meynier A, et al. 2016. Bioavailability of lipids in fish and fish oils. In: Raatz SK, Bibus DM, eds. Fish and fish oil in health and disease prevention. London: Academic Press. [Google Scholar]
  • Ghanim H, Sia CL, et al. 2010. Orange juice neutralizes the proinflammatory effect of a high-fat, high-carbohydrate meal and prevents endotoxin increase and Toll-like receptor expression. Am J Clin Nutr 91 (4): 940–949. [CrossRef] [PubMed] [Google Scholar]
  • Ghoshal S, Witta J, et al. 2009. Chylomicrons promote intestinal absorption of lipopolysaccharides. J Lipid Res 50 (1): 90–97. [CrossRef] [PubMed] [Google Scholar]
  • Hailman E, Lichenstein HS, et al. 1994. Lipopolysaccharide (LPS)-binding protein accelerates the binding of LPS to CD14. J Exp Med 179 (1): 269–277. [CrossRef] [PubMed] [Google Scholar]
  • Harris HW, Grunfeld C, et al. 1993. Chylomicrons alter the fate of endotoxin, decreasing tumor necrosis factor release and preventing death. J Clin Invest 91 (3): 1028–1034. [CrossRef] [PubMed] [Google Scholar]
  • Harris HW, Rockey DC, et al. 1998. Chylomicrons alter the hepatic distribution and cellular response to endotoxin in rats. Hepatology 27 (5): 1341–1348. [CrossRef] [PubMed] [Google Scholar]
  • Harte AL, Varma MC, et al. 2012. High fat intake leads to acute postprandial exposure to circulating endotoxin in type 2 diabetic subjects. Diabetes Care 35 (2): 375–382. [CrossRef] [PubMed] [Google Scholar]
  • Hiki N, Berger D, et al. 1999. Changes in endotoxin-binding proteins during major elective surgery: Important role for soluble CD14 in regulation of biological activity of systemic endotoxin. Clin Diagn Lab Immunol 6 (6): 844–850. [PubMed] [Google Scholar]
  • Kenmogne-Domguia HB, Moisan S, et al. 2014. The initial characteristics of marine oil emulsions and the composition of the media inflect lipid oxidation during in vitro gastrointestinal digestion. Food Chem 152: 146–154. [CrossRef] [PubMed] [Google Scholar]
  • Keogh JB, Wooster TJ, et al. 2011. Slowly and rapidly digested fat emulsions are equally satiating but their triglycerides are differentially absorbed and metabolized in humans. J Nutr 141 (5): 809–815. [CrossRef] [PubMed] [Google Scholar]
  • Kidd PM. 2007. Omega-3 DHA and EPA for cognition, behavior, and mood: clinical findings and structural-functional synergies with cell membrane phospholipids. Altern Med Rev 12 (3): 207–227. [PubMed] [Google Scholar]
  • Kullenberg D, Taylor LA, et al. 2012. Health effects of dietary phospholipids. Lipids Health Dis 11: 3. [CrossRef] [PubMed] [Google Scholar]
  • Lakatos PL, Kiss LS, et al. 2011. Serum lipopolysaccharide-binding protein and soluble CD14 are markers of disease activity in patients with Crohn's disease. Inflamm Bowel Dis 17 (3): 767–777. [CrossRef] [PubMed] [Google Scholar]
  • Langsted A, Nordestgaard BG. 2015. Nonfasting lipid profiles: the way of the future. Clin Chem 61 (9): 1123–1125. [CrossRef] [PubMed] [Google Scholar]
  • Lassenius MI, Pietilainen KH, et al. 2011. Bacterial endotoxin activity in human serum is associated with dyslipidemia, insulin resistance, obesity, and chronic inflammation. Diabetes Care 34 (8): 1809–1815. [CrossRef] [PubMed] [Google Scholar]
  • Laugerette F, Vors C, et al. 2011a. Emulsified lipids increase endotoxemia: possible role in early postprandial low-grade inflammation. J Nutr Biochem 22: 53–59. [CrossRef] [PubMed] [Google Scholar]
  • Laugerette F, Vors C, et al. 2011b. Complex links between dietary lipids, endogenous endotoxins and metabolic inflammation. Biochimie 93 (1): 39–45. [CrossRef] [Google Scholar]
  • Laugerette F., Furet JP, et al. 2012. Oil composition of high dat diet affects differently metabolic inflammation in connexion with endotoxin receptors in mice. Am J Physiol Endocrinol Metab 302: E374–E386. [CrossRef] [PubMed] [Google Scholar]
  • Laugerette F, Alligier M, et al. 2014. Overfeeding increases postprandial endotoxemia in men: Inflammatory outcome may depend on LPS transporters LBP and sCD14. Mol Nutr Food Res 58 (7): 1513–1518. [CrossRef] [PubMed] [Google Scholar]
  • Laville M, Vors C, Nazare JA, Michalski MC. 2013. Intérêt de la phase postprandiale pour la santé de l’Homme. Bull Acad Natl Med 197(1): 65–77. [Google Scholar]
  • Lecomte M, Bourlieu C, et al. 2015. Milk polar lipids affect in vitro digestive lipolysis and postprandial lipid metabolism in mice. J Nutr 145 (8): 1770–1777. [CrossRef] [PubMed] [Google Scholar]
  • Lecomte M, Coudelo L, et al. 2016. Dietary emulsifiers from milk and soybean differently impact adiposity and inflammation in association with modulation of colonic goblet cells in high-fat fed mice. Mol Nutr Food Res 60 (3): 609–620. [CrossRef] [PubMed] [Google Scholar]
  • Lecomte M, Coudelo L, et al. 2017. Soybean polar lipids differently impact adipose tissue inflammation and the endotoxin transporters LBP and sCD14 in flaxseed vs palm oil-rich diets. J Nutr Biochem 43: 116–124. [CrossRef] [PubMed] [Google Scholar]
  • Libby P. 2002. Inflammation in atherosclerosis. Nature 420: 868–874. [CrossRef] [PubMed] [Google Scholar]
  • Matsushita H, Ohta S, et al. 2010. Endotoxin tolerance attenuates airway allergic inflammation in model mice by suppression of the T-cell stimulatory effect of dendritic cells. Int Immunol 22 (9): 739–747. [CrossRef] [PubMed] [Google Scholar]
  • Michalski MC. 2009. Specific molecular and colloidal structures of milk fat affecting lipolysis, absorption and postprandial lipemia. Eur J Lipid Sci Technol 111 (5): 413–431. [CrossRef] [Google Scholar]
  • Michalski MC, Vors C. 2013. Impact de la matrice laitière sur le devenir des acides gras. Cholédoc 138 (11–12): 1–6. [Google Scholar]
  • Michalski MC, Briard V, et al. 2005. The dispersion state of milk fat influences triglyceride metabolism in the rat − A (CO2)-C-13 breath test study. Eur J Nutr 44 (7): 436–444. [CrossRef] [PubMed] [Google Scholar]
  • Michalski MC, Soares AF, et al. 2006. The supramolecular structure of milk fat influences plasma triacylglycerols and fatty acid profile in the rat. Eur J Nutr 45 (4): 215–224. [CrossRef] [PubMed] [Google Scholar]
  • Michalski MC, Genot C, et al. 2013. Multiscale structures of lipids in foods as parameters affecting fatty acid bioavailability and lipid metabolism. Prog Lipid Res 52 (4): 354–373. [CrossRef] [PubMed] [Google Scholar]
  • Michalski MC, Vors C, et al. 2016. Dietary lipid emulsions and endotoxemia. OCL Oils Fat Crop Lipid 23: 3. [Google Scholar]
  • Nabli F, Ricroch L. 2012. Enquête Emploi du temps 2009–2010. INSEE Résultats (130), société. Disponible sur [Google Scholar]
  • Nordestgaard BG, Benn M, et al. 2007. Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women. JAMA 298 (3): 299–308. [CrossRef] [PubMed] [Google Scholar]
  • Norris GH, Jiang C, et al. 2016. Milk sphingomyelin improves lipid metabolism and alters gut microbiota in high fat diet-fed mice. J Nutr Biochem 30: 93–101. [CrossRef] [PubMed] [Google Scholar]
  • Osborn MJ, Rosen SM, et al. 1964. Lipopolysaccharide of the Gram-negative cell wall. Science 145: 783–789. [CrossRef] [PubMed] [Google Scholar]
  • Pastor Rojo O, Lopez San Roman A, et al. 2007. Serum lipopolysaccharide-binding protein in endotoxemic patients with inflammatory bowel disease. Inflamm Bowel Dis 13 (3): 269–277. [CrossRef] [PubMed] [Google Scholar]
  • Raatz SK, Redmon JB, et al. 2009. Enhanced absorption of n-3 fatty acids from emulsified compared with encapsulated fish oil. J Am Diet Assoc 109 (6): 1076–1081. [CrossRef] [PubMed] [Google Scholar]
  • Raynal-Ljutovak K, Bouvier J, et al. 2011. Organisation structurale et moléculaire des lipides dans les aliments : impacts possibles sur leur digestion et leur assimilation par l'homme. OCL 18 (6): 324–351. [CrossRef] [EDP Sciences] [Google Scholar]
  • Ross R. 1999. Atherosclerosis is an inflammatory disease. Am Heart J 138 (5 Pt 2): S419–S420. [CrossRef] [PubMed] [Google Scholar]
  • Stoll LL, Denning GM, et al. 2004. Regulation of endotoxin-induced proinflammatory activation in human coronary artery cells: expression of functional membrane-bound CD14 by human coronary artery smooth muscle cells. J Immunol 173 (2): 1336–1343. [CrossRef] [PubMed] [Google Scholar]
  • Sugasini D, Lokesh BR. 2013. Enhanced incorporation of docosahexaenoic acid in serum, heart, and brain of rats given microemulsions of fish oil. Mol Cell Biochem 382 (1–2): 203–216. [CrossRef] [PubMed] [Google Scholar]
  • Tou JC, Jaczynski J, et al. 2007. Krill for human consumption: nutritional value and potential health benefits. Nutr Rev 65 (2): 63–77. [PubMed] [Google Scholar]
  • Tressou-Cosmao J, Pasteau S, Le Guillou C, Simon N. 2015. Analyse des apports nutritionnels en acides gras de la population française à partir des données INCA 2. Rapport ONIDOL-Terres Univia – février 2015. Disponible sur, mis à jour septembre 2015. [Google Scholar]
  • Vors C, Pineau G, et al. 2013. Modulating absorption and postprandial handling of dietary fatty acids by structuring fat in the meal: a randomized crossover clinical trial. Am J Clin Nutr 97 (1): 23–36. [CrossRef] [PubMed] [Google Scholar]
  • Vors C, Gayet-Boyer C, et al. 2014. Produits laitiers et inflammation métabolique : quels liens en phase postprandiale et à long terme ? Cah Nutr Diet 50 (1): 25–38. [CrossRef] [Google Scholar]
  • Vors C, Pineau G, et al. 2015. Postprandial endotoxemia linked with chylomicrons and lipopolysaccharides handling in obese versus lean men: a lipid dose-effect trial. J Clin Endocrinol Metab 100 (9): 3427–3435. [CrossRef] [PubMed] [Google Scholar]
  • Vors C, Lecomte M, et al. 2016. Impact de la structure émulsionnée des lipides sur le devenir métabolique des acides gras alimentaires. Cah Nutr Diet 51 (5): 238–247. [CrossRef] [Google Scholar]
  • Vreugdenhil AC, Rousseau CH, et al. 2003. Lipopolysaccharide (LPS)-binding protein mediates LPS detoxification by chylomicrons. J Immunol 170 (3): 1399–1405. [CrossRef] [PubMed] [Google Scholar]

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