| Issue |
OCL
Volume 30, 2023
|
|
|---|---|---|
| Article Number | 10 | |
| Number of page(s) | 8 | |
| Section | Nutrition - Health | |
| DOI | https://doi.org/10.1051/ocl/2023008 | |
| Published online | 08 June 2023 | |
Médaille Chevreul
F4-neuroprostanes and F2-dihomo-isoprostanes: biomarkers and bioactive oxylipins
F4-neuroprostanes et F2-dihomo-isoprostanes : biomarqueurs et oxylipines bioactives
Institut des Biomolécules Max Mousseron IBMM, Pôle Recherche Chimie Balard, UMR 5247 Université Montpellier, CNRS, ENSCM, 1919 route de Mende, F-34293 Montpellier Cedex 05, France
* Correspondence: thierry.durand@umontpellier.fr
Received:
1
May
2023
Accepted:
13
May
2023
Under condition of oxidative stress, free radical-catalyzed peroxidation of docosahexaenoic acid (DHA) and adrenic acid (AdA) generates in vivo neuroprostanes (NeuroPs) and dihomo-isoprostanes (dihomo-IsoPs), among a large number of key products participating in many pathophysiological processes. These non-enzymatic oxygenated metabolites display a wide range of biological actions (especially DHA-metabolites), and some of them are now considered as the most reliable indicators of oxidative stress in neurogenerative, neurodevelopmental or cardiovascular diseases. In this review, we will present an overview regarding neuroprostanes and dihomo-isoprostanes and discuss about their biological interests.
Résumé
Dans des conditions de stress oxydatif, la peroxydation, catalysée par les radicaux libres de l’acide docosahexaénoïque (DHA) et de l’acide adrénique (AdA) génère, parmi un grand nombre de produits clés participant à de nombreux processus physiopathologiques, des neuroprostanes (NeuroPs) et dihomo-isoprostanes (dihomo-IsoPs). Ces métabolites oxygénés non-enzymatiques présentent de nombreuses activités biologiques, et certains d’entre eux sont désormais considérés comme les biomarqueurs les plus fiables du stress oxydatif dans les maladies neurogénératives, neurodéveloppementales ou encore cardiovasculaires. Dans cette revue, seront présentés les différents travaux autour des neuroprostanes et dihomo-isoprostanes, et notamment leur intérêt biologique.
Key words: biomarkers / docosahexaenoic acid / radical peroxidation / neuroprostanes / dihomo-isoprostanes / bioactive oxylipins / total synthesis
Mots clés : biomarqueurs / activités biologiques / peroxydation lipidique / acides gras polyinsaturés / neuroprostanes / dihomo-isoprostanes
© T. Durand et al., Published by EDP Sciences, 2023
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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