Bioinformatics exploration of olive oil: molecular targets and properties of major bioactive constituents | OCL

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Table 1

Predicted human protein targets of selected bioactive compounds of olive oil.

S.No	Target			Ligands and percentage (%) probability of binding on target

	Name	Gene ID	UniProt ID	Linoleic acid	Maslinic acid	Melatonin	Oleanolic acid	Oleic acid	Tyrosol
1	Melatonin receptor 1A	MTNR1A	P48039			100
2	Melatonin receptor 1B	MTNR1B	P49286			100
3	Quinone reductase 2	NQO2	P16083			100
4	Serotonin 2b (5-HT2b) receptor	HTR2B	P41595			40
5	Fatty acid binding protein adipocyte	FABP4	P15090	65				100
6	Anandamide amidohydrolase	FAAH	O00519					100
7	Peroxisome proliferator-activated receptor gamma	PPARG	P37231	75				100
8	Peroxisome proliferator-activated receptor alpha	PPARA	Q07869	75				100
9	Telomerase reverse transcriptase	TERT	O14746					100
10	Fatty acid binding protein epidermal	FABP5	Q01469					100
11	Peroxisome proliferator-activated receptor delta	PPARD	Q03181	75				100
12	Free fatty acid receptor 1	FFAR1	O14842	75
13	Fatty acid-binding protein, liver	FABP1	P07148					100
14	Fatty acid binding protein muscle	FABP3	P05413	60				60
15	Acyl-CoA desaturase	SCD	O00767	30				50
16	Cyclooxygenase-1	PTGS1	P23219	50
17	Carbonic anhydrase II	CA2	P00918						100
18	Protein-tyrosine phosphatase 1B	PTPN1	P18031		70		95
19	DNA polymerase beta	POLB	P06746		45		70
20	Aldo-keto reductase family 1 member B10	AKR1B10	O60218		55		70
21	Nuclear receptor ROR-gamma	RORC	P51449		40		60
22	Receptor-type tyrosine-protein phosphatase F (LAR)	PTPRF	P10586		40		60
23	T-cell protein-tyrosine phosphatase	PTPN2	P17706		40		60
24	11-beta-hydroxysteroid dehydrogenase 1	HSD11B1	P28845		60		60
25	Low molecular weight phosphotyrosine protein phosphatase	ACP1	P24666		40		60
26	Dual specificity phosphatase Cdc25B	CDC25B	P30305		40		55
27	Phosphodiesterase 4D	PDE4D	Q08499		35		50
28	CD81 antigen	CD81	P60033		45		50
29	Phospholipase A2 group 1B	PLA2G1B	P04054		40		50

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