Issue |
OCL
Volume 19, Number 4, Juillet-Août 2012
|
|
---|---|---|
Page(s) | 228 - 231 | |
Section | Dossier : Absorption intestinale des lipides | |
DOI | https://doi.org/10.1051/ocl.2012.0463 | |
Published online | 15 July 2012 |
Conséquences métaboliques des malabsorptions lipidiques : apports de l’étude des hypocholestérolémies familiales
Metabolic consequences of intestinal malabsorption of lipids: how studying hereditary hypocholesterolemia improves our knowledge
1
Hospices Civils de Lyon, Hôpital Femme Mère Enfant de Lyon, Bron, F-69677, France
2
Université de Lyon, INSERM U1060, CarMeN laboratory, Lyon, F-69008
France
3
Université Lyon 1, Faculté de Médecine Lyon-Est, Lyon, F-69003, France
Reçu :
11
Mai
2012
Accepté :
13
Juin
2012
Abstract
Familial hypocholesterolemia, namely abetalipoproteinemia, hypobetalipoproteinemia and chylomicron retention disease (CRD), are rare genetic diseases that cause intestinal lipid malabsorption. They provide a model to study the consequences of chronic hypocholesterolemia: protection against cardiovascular disease, increase of fatty liver disease and neurovascular complications. The understanding of their physiopathology provided new approaches to treat hypercholesterolemia.
Key words: familial hypocholesterolemia / abetalipoproteinemia / hypobetalipoproteinemia / chylomicron retention disease (CRD) / intestinal lipid malabsorption / chronic hypocholesterolemia
© John Libbey Eurotext 2012
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