Volume 18, Number 4, Juillet-Août 2011Lipids and Brain II. Actes des Journées Chevreul 2011 (Première partie)
|Page(s)||202 - 207|
|Section||PUFA and Depression|
|Published online||15 July 2011|
Spadin, a Sortilin-derived peptide: a new concept in the antidepressant drug design
Institut de pharmacologie moléculaire et cellulaire, CNRS, Université de Nice Sophia Antipolis, 660 Route des Lucioles, 06560
Depression is the most common of psychiatric illnesses. The design of effective treatments for this disorder is a challenging process. Recently, the two-pore domain potassium channel TREK-1 has been identified as a new target in depression, and its antagonists might become effective antidepressants. Deletion of TREK-1 gene results in a depression-resistant phenotype that mimics antidepressant treatments. Here, we validate the fast antidepressant effects of spadin, a secreted peptide derived from the propeptide generated by the maturation of the sortilin receptor and acting through TREK-1 inhibition.
Key words: Spadin / TREK-1 channel / depression / behavior
© John Libbey Eurotext 2011
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