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Home All issues Volume 32 (2025) OCL, 32 (2025) 5 Full HTML
Extraction solvents / Solvants d’extraction
Open Access
Erratum
This article is an erratum for:
[https://doi.org/10.1051/ocl/2024028]

Table 1

Classification and labelling of the solvent according to ECHA/REACH documentation.

Solvent Hexane Iso-Hx Cycl Hex MeOH EtOH IPA Acetone MEK EA DCM 2-MeOx
CAS RN 110-54-3 107-83-5 110-82-74 67-56-1 64-17-5 67-63-0 67-64-1 78-93-3 141-78-6 75-09-2 96-47-9
Occupational Exposure Limit (ECHA, ppm) 20     200 – – 500 200 200 100  
France VLE /8h (ppm, molar) 20 500 200 200 1000 (400 CT) 500 200 200 50  
Germany (MAK) 50 500   200 200 200 500        
Flammable                      
Acute toxicity                      
Health hazard                      
Nocive or irrit.                      
Envion. hazard                      
Corrosive                      
Properties of concern Repro-toxic *       Cancer **         Cancer + endoc***  
LD 50 oral (g/kg) 0.024-0.049 0.0158 5 1.19-2.77 1.18 − 15.0 5.84 5.8 2-6 10.19 2 0.3
Flam. Liq. 2 H225 ✔ ✔ ✔   ✔ ✔ ✔ ✔ ✔   R
Acute Tox. 3 H301       ✔              
Acute Tox. 4 H302         R         n R
Asp. Tox. 1 H304 ✔ ✔ ✔                
Acute Tox. 3 H311       ✔              
Skin Irritant 2 H315 ✔ ✔ ✔   n         R R
Eye dam. 1 H318                     R
Eye Irritant 2 H319 R n     R ✔ ✔ ✔ ✔ R n
Acute Tox. 3 H331       ✔              
STOT SE 3 H335   n       n   n   n n
STOT SE 3 H336 ✔ ✔ ✔     ✔ ✔ ✔ ✔ R n
Mutagen 2 H341                   n  
Carcinogen. B1 H350         R            
Carcinogen. 2 H351       n           ✔  
Reprotoxic 2 H361f ✔                    
STOT SE 1 H370       ✔ R            
STOT SE 2 H371         R   n        
STOT RE 1 H372 n                    
STOT RE 2 H373 ✔                 n  
Aquatic Ac. 1 H400   n ✔                
Aquatic Chr 1 H410   n ✔                
Aquatic Ch 2 H411 ✔ ✔                  

(*) suspected to be toxic to reproduction; (**) Some submitters consider as carcinogenic; (***) Suspected carcinogenic & under assessment for endocrine disruption.

The symbol “✔” is present when the danger is recognized in the “harmonised classification and labelling” approved by the EU; R when the danger is identified by a large number of companies filling a reach registration; “n” is for dangers notified by a few suppliers to ECHA.

REACH: Registration, Evaluation, Authorisation and Restriction of Chemicals.

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