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Evolution of human milk PUFAs in USA since 1930: increase of LA (18:2n-6). Linoleic acid (LA; C18 :2 n-6 ; black circles) and α-linolenic acid (ALA; C18:3 n-3; open circles) content in mature breast milk of US women. By courtesy of authors. Adapted from Ailhaud et al. (2006) till 2013. For 18:2n-6, Y = −0.0014 × 2 + 5.738x−5789, R2 = 0.56, P < 0.01 for n = 48. For 18:3n-3, Y = 0.0041x−6.915, R2 = 0.023, NS for n = 39).

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