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Table 1

Compared human breast milk, cow milk and infant formula composition.

Adapted from (Malacarne et al., 2002; Brenna et al., 2007; Ballard and Morrow, 2013; Delplanque et al., 2015).

/ 100 ml Human milk Cow milk Infant fomulaa
Energy (Kcal) 65–70 (57–83) 67.4 (65–71.2) 60–70
Proteins (g) 1.20 (0.9–1.7) 3.25 (3.1–3.8) 1.1–2.1
   Caseins (g) 0.37 (0.32–0.42) 2.51 (2.46–2.80) 0.4–0.8
      α-Caseins (%) 11.8 (11.1–12.5) 48.5 (48.3–48.5)  
      β-Casein (%) 64.8 (62.5–66.7) 35.8 (35.8–37.9)  
      κ-Casein (%) 23.5 (22.2–25.0) 12.7 (12.7–13.8)  
      Size of micelles (nm) 64 182  
   Whey proteins (g) 0.76 (0.68–0.83) 0.57 (0.55–0.70) 0.6–1.3
      β-lactoglobulin (%) Absent 20.1 (18.4–20.1)  
      α-lactalbumin (%) 42.4 (30.3–45.4) 53.6 (52.9–53.6)  
      Immunoglobulins (%) 18.2 (15.1–19.7) 11.7 (10.1–11.7)  
      Serum albumin (%) 7.6 (4.5–9.1) 6.2 (5.5–7.7)  
      Lactoferrin (%) 30.3 8.4  
      Lysozyme (%) 1.66 Traces  
      Caseins/Whey proteins 30–40/60–70 80/20 40/60
Fat (g) 3.2–3.6 (1.2–5.2) 3.6 (1.2–7.9) 2.6–4
   Triglycerides (%) 98.1–98.8 97.0  
   Phospholipids (%) 0.26–0.8 1.5 ≤ 7
   Cholesterol (mg/100 mL) 10–20 1.0–33 Absent
   
   % Fatty acids relative to total fatty acids      
      Butyric (C4:0) 0.1 1.4 (1.4–3.3) nqb
      Caproic (C6:0) 0.2 2.1 (1.6–2.2) 0.1
      Caprylic (C8:0) 0.3 (0.1–0.3) 1.7 (1.3–1.8) 1.0–1.5
      Capric (C10:0) 2.0 (1.1–2.1) 3.5 (3.0–3.6) 0.9–1.3
      Lauric (C12:0) 6.8 (3.1–7.2) 3.9 (3.1–4.0) 7.8–11.5
      Myristic (C14:0) 10.4 (5.1–10.9) 12.6 (13.0–14.2) 4.0–5.5
      Palmitic (C16:0) 28.1 (20.2–29.6) 29.5 (24.0–42.7) 18.2–25.4
      Palmitoleic (C16:1) 3.5 (3.5–5.7) 1.7 0.1–0.2
      Stearic (C18:0) 6.9 (6.0–8.6) 13.3 (5.7–13.7) 3.5–4.0
      Oleic (C18:1) 33.6 (33.3–46.4) 26.3 (16.7–27.1) 28.4–40.8
   n-6 PUFA      
      Linoleic (C18:2) 17 (6.0–24) 2.9 (1.6–3.0) 13.3–18.5
      Arachidonic (C20:4) 0.5 (0.25–0.75)   Added:0.2–0.6 / not added: nq
   n-3 PUFA      
      α-linolenic (C18:3) 1.7 (1.0–3.4) 1.1 (0.5–1.8) 1.6–2.4
      Docosahexaenoic (C22:6) 0.32 (0.10–0.60)   Added:0.2–0.3 / not added: nq
Carbohydrates (g) 7.4–7.8 (6.0–9.6) 4.5 5.4–9.5
   Lactose (%) 85 100 47–100
   Oligosaccharides (%) 0.5–2.0 Traces  
   Maltodextrin (g) Absent Absent 1.1–2.6
  
Minerals (g) 0.21 0.90 0.25–0.50
   Na (mg) 16 48 12–42
   Ca (mg) 33 125 30–98
   K (mg) 16.5 100 36–112
   Fe (mg) 0.05 0.03 0.2–0.9
   Mg (mg) 5 10  
   P (mg) 20 84  

Mean value and, between brackets minimum–maximum values, reported in literature.

a

Lipid composition provided in this table is that of an infant formula based of a blend of plant oils including palm oil and coconut oil, as an example of infant formula made with plant oils as lipid source.

b

Nq, non quantifiable amount (< 0.05%).

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