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An overview of phospholipids turnover, arachidonic acid, and eicosanoid signaling in schizophrenia symptomatology (adapted from Skosnik and Yao, 2003). Abbreviations: AODS, antioxidant defense system; NT, neurotransmitters; RO, reactive oxygen species; apoD, apolipoprotein D; PLA2, phospholipase A2; PLC, phospholipase C; LOX, lipooxygenase; AA, arachidonic acid; DAG, diacylglycerol; COX, cyclooxygenase; 2-AG, 2-arachidonoyl glycerol; GAP, growth-associated protein; PKC, phosphokinase C; PGG2. prostaglandin G2; PGH2, prostaglandin H2; PGD2, prostaglandin D2; CB, cannabinoid.
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