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Table 1

Epidemiological studies showing an interaction between LC n-3 PUFA and APOE genotype on cognition.

Reference Exposure Outcome APOE4 carriers APOE4 non-carriers

Measure of association Measure of association
(95% CI) or P value (95% CI) or P value

(Huang Fatty fish: 2 to 4 8-yr incidence HR = 0.91 (0.48 to 1.71) HR = 0.60 (0.40 to 0.89)
et al., 2005) servings per week of dementia

(Barberger-Gateau Fish at least 4-yr incidence HR = 1.28 (0.58 to 2.83) HR = 0.60 (0.41 to 0.89)
et al., 2007) once a week of dementia

(Beydoun EPA + DHA in Cognitive OR = 0.80 (0.45 to 1.63) for 1 SD OR = 0.61 (0.43 to 0.87)
et al., 2007) plasma cholesteryl decline on Word for 1 SD
esters Fluency Test

(Whalley Total LC n-3 PUFA Cognitive r = 0.02 r = 0.35
et al., 2008) in erythrocyte performance on a NS P< 0.01
membranes score derived by PCA

(Samieri EPA and DHA in Cognitive DHA: β = 0.061, P = 0.01 DHA: NS
et al., 2011) total plasma fatty decline on EPA: β = 0.077, P = 0.003 EPA: NS except in subjects
acids (for 1 SD) Benton Visual in subjects with low depressive symptoms with high depressive
Retention Test β = 0.172, P< 0.001 symptoms
in subjects with high depressive symptoms

HR = hazard ratio, OR = odds ratio, CI = confidence interval, SD = standard deviation, PCA = principal component analysis, NS = not significant.

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