Open Access
Table 1
Epidemiological studies showing an interaction between LC n-3 PUFA and APOE genotype on cognition.
| Reference | Exposure | Outcome | APOE4 carriers | APOE4 non-carriers |
|
|
||||
| Measure of association | Measure of association | |||
| (95% CI) or P value | (95% CI) or P value | |||
|
|
||||
| (Huang | Fatty fish: 2 to 4 | 8-yr incidence | HR = 0.91 (0.48 to 1.71) | HR = 0.60 (0.40 to 0.89) |
| et al., 2005) | servings per week | of dementia | ||
|
|
||||
| (Barberger-Gateau | Fish at least | 4-yr incidence | HR = 1.28 (0.58 to 2.83) | HR = 0.60 (0.41 to 0.89) |
| et al., 2007) | once a week | of dementia | ||
|
|
||||
| (Beydoun | EPA + DHA in | Cognitive | OR = 0.80 (0.45 to 1.63) for 1 SD | OR = 0.61 (0.43 to 0.87) |
| et al., 2007) | plasma cholesteryl | decline on Word | for 1 SD | |
| esters | Fluency Test | |||
|
|
||||
| (Whalley | Total LC n-3 PUFA | Cognitive | r = 0.02 | r = 0.35 |
| et al., 2008) | in erythrocyte | performance on a | NS | P< 0.01 |
| membranes | score derived by PCA | |||
|
|
||||
| (Samieri | EPA and DHA in | Cognitive | DHA: β = 0.061, P = 0.01 | DHA: NS |
| et al., 2011) | total plasma fatty | decline on | EPA: β = 0.077, P = 0.003 | EPA: NS except in subjects |
| acids (for 1 SD) | Benton Visual | in subjects with low depressive symptoms | with high depressive | |
| Retention Test | β = 0.172, P< 0.001 | symptoms | ||
| in subjects with high depressive symptoms | ||||
HR = hazard ratio, OR = odds ratio, CI = confidence interval, SD = standard deviation, PCA = principal component analysis, NS = not significant.
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.