DHA transport through the blood to eye and brain tissues Liver-derived DHA reaches the eyes and the brain (two tissues highly enriched in DHA) through the general circulation, most likely as a complex with lipid-binding proteins (e.g., albumin) that are also synthesized in the hepatocytes. Once in the brain, free DHA is in equilibrium with complex lipids (e.g., phosphatidylethanolamines) and metabolites (e.g., neuroprotectins). The figure shows chemical structures of DHA-derived lipids quantified in our analyses.