Volume 19, Number 4, Juillet-Août 2012
|Page(s)||196 - 199|
|Section||Dossier : Absorption intestinale des lipides|
|Published online||15 July 2012|
Détection luminale des micelles lipidiques
Intestinal sensing of postprandial lipid micelles
Unité mixte de recherche UMRS-872, INSERM UPMC UPD, Centre de Recherche des Cordeliers, équipe 4, 15 rue de l’école de médecine, 75006 Paris, France
Accepté : 30 Janvier 2012
Post-prandial hypertriglyceridemia is a risk factor for metabolic diseases. The intestine, through its role in alimentary lipid absorption, participates in the secretion of lipoprotein rich-triglycerides (TRL) and contributes to the increase in plasma triglyceride levels during the postprandial state. Understanding the molecular mechanisms involved in the secretion of intestinal TRL would allow the identification of new drug targets for treatment of metabolic diseases. The sensing of lipids by intestinal cells represents a promising mechanism allowing the modulation of TRL secretion. While many studies show the importance of enteroendocrine cells in the detection of alimentary lipids, several evidence suggest also the implication of enterocytes, the absorptive intestinal cells, in this process. Recent experimental results on the role of the scavenger receptor SR-BI in the detection of dietary lipids, supplied in their physiological form of postprandial lipid micelles, are reviewed.
Key words: intestine / enterocytes / enteroendocrine cells / sensing / lipid micelles / SR-BI
© John Libbey Eurotext 2012
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.