Volume 18, Number 2, Mars-Avril 2011Dossier : Vitamines liposolubles
|Page(s)||76 - 82|
|Section||Nutrition – Santé|
|Published online||15 March 2011|
Coenzyme Q 10: multiple benefits in one ingredient
Department of Biochemistry, Biology & Genetics, Polytechnic University of the Marche, 60131 Ancona, Italy
2 Kaneka Pharma Europe NV, Brussels, Belgium
Coenzyme Q is a lipid molecule widely diffused in nature; in humans and other mammals it is present as coenzyme Q10. (CoQ10). The first recognized role of CoQ10 was in mitochondrial bioenergetics, where it plays a central role in the production of ATP. It is also present in other subcellular organelles, both in its oxidized and in its reduced state (ubiquinol-10). The reduced form of CoQ10 is endowed with powerful antioxidant activity: it acts as a chain-breaking antioxidant and is also capable of egenerating alpha-tocopherol, the active form of vitamin E. By these mechanisms CoQ10, together with vitamin E, protects lipoproteins from oxidation a process which bears considerable interest in preventing atherosclerosis. CoQ10 has also been found to support cardiovascular function and the latest findings indicate an active role in counteracting endothelial dysfunction, which is closely implicated in cardiovascular disease. CoQ10 also improves sperm motility, an effect which might be related both to its antioxidant and to its bioenergetic properties. Oxidative stress might be involved in neurodegenerative disease, and in migraine, two fields where the positive effects of CoQ10 have been documented. CoQ10 is synthesized by our body but is also present in food and can be taken as a nutritional supplement. The main source of industrially produced CoQ10 is yeast fermentation. The process results in CoQ10 which is identical to the naturally occurring molecule. Ubiquinol, the reduced form of CoQ10, has recently become available.
Key words: Coenzyme Q10 / bioenergetics / antioxidation / skin metabolism / fermentation / nutritional claims
© John Libbey Eurotext 2011
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