Open Access
Volume 31, 2024
Article Number 13
Number of page(s) 6
Section Nutrition - Health
Published online 01 July 2024

© C. Doussat et al., Published by EDP Sciences, 2024

Licence Creative CommonsThis is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


  • Omega-3 fatty acids have multiple beneficial effects on skeletal muscle

  • EPA and DHA, whose sources are exclusively marine, mediate these effects

  • Finding diverse sources of omega-3 fatty acids is essential, as marine ressources are overexploited

1 Introduction

The multiple metabolic roles of omega-3 fatty acids are well known. Their major effects are their anti-inflammatory action through their metabolites involved in resolving inflammation, and their competition with omega-6 fatty acids, pro-inflammatory molecules (Gammone et al., 2018). In addition, they are thought to play a role in the prevention of cardiovascular disease by lowering blood triglycerides, increasing high density lipoprotein (HDL) concentration and decreasing platelet aggregation (Jeromson et al., 2015). At the same time, their effects on muscle have been studied and these effects seems of particular interest in various pathophysiological situations such as physical activity, obesity, sarcopenia and cachexia. This review aims to give a brief overview of the current knowledge regarding the effect of dietary omega 3 effect on skeletal muscle. After a brief overview of omega-3 fatty acid metabolism, we will discuss the potential mechanisms through which these fatty acids could enhance physical activity and sports performance. Additionally, we will examine their role in the prevention of certain metabolic disorders linked to obesity, as well as their potential to prevent the loss of muscle mass and function during aging and in cancer.

2 Method

Bibliographic searches focused on the PubMed database. Keywords were “omega 3 OR n 3 PUFA AND skeletal muscle”; “omega 3 OR n 3 PUFA AND skeletal muscle AND obesity”; “omega 3 OR n 3 PUFA AND cancer cachexia”; “omega 3 AND obesity” with a publication date restriction between 2002 and November 2023. Priority was given to systematic reviews and publications explaining the mechanics of the actions. They were only included if they studied the metabolic effects of omega 3 on skeletal muscle, particularly in the fields of sport, obesity, sarcopenia or cachexia. Twenty-seven papers were finally included.

Some recalls about omega 3

The precursor of the group of omega-3 fatty acids is alpha-linolenic acid (ALA), synthesized only by plants, which makes it essential in the human diet. ALA is metabolized in human body by elongases and desaturases leading to the formation of eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA) and docosahexaenoic acid (DHA) (Jeromson et al., 2015). More specifically,  alpha-linolenic acid is converted to EPA by elongation of the fatty acyl chain and insertion of two additional double bonds into it. EPA is further metabolised to DHA through a complex set of reactions involving chain elongation, desaturation (insertion of a double bond) and partial oxidation. Desaturation and elongation reactions occurs in the endoplasmic reticulum and are followed by a final peroximal beta-oxidation process (Videlaet al., 2022). Delta-6 desaturase and delta-5 desaturase catalyse the formation of a double bound in the 6th and the 5th carbon from the carboxylic end, respectively (Videla et al., 2022), the two-carbon elongation are carried out by elongases 2 and 5, whereas beta-oxidation leads to the production of DHA.  According to a recent study conducted in mice by Valenzuela et al. (2024), liver have the highest capacity for PUFA biosynthesis, while activity is limited in brain, testicles, and kidney, and not detectable in heart and lung. The conversion rate of ALA to EPA in human is between 8% and 12%, while that of ALA to DHA is around 1% (Brenna, 2002). In a number of diseases associated to oxidative stress, including overnutrition-induced obesity that leads to non-alcoholic fatty liver disease, a drastic lowering in the hepatic activity of delta-5 desaturase and delta-6 desaturase is observed, as a consequence of oxidative stress. This leads to a depletion of omega-3 fatty acids in the liver, with a negative impact on their systemic abundance (Videla et al., 2022).

Dietary sources of omega-3 are various. ALA is found mainly in plant foods, such as walnuts and walnut oil, flaxseed and flaxseed oil, chia seeds, soybeans, rapeseed oil and seaweed. ALA is also found in animal products when animals consume plant sources of ALA. EPA or DHA are exclusively of marine origin: fish, especially oily fish such as mackerel, sardines and herring, as well as seaweed.

According to the French Agency for Food, Environmental and Occupational Health Safety (ANSES 2016), daily adequate intake are 250 mg for EPA, 250 mg for DHA, and 1% of total daily energy intake for ALA. The French National Nutrition and Health Program (PNNS) 4 recommends eating two portions of fish per week, including one of oily fish, and encourages consumption of rapeseed or walnut oil. 

EPA and DHA are metabolically more active than ALA which is then mainly considered as a precursor of EPA and DHA. Indeed, oxylipins including resolvins, protectins and maresins, are produced from EPA and DHA by cyclooxygenases, lipoxygenases and cytochrome P450 (Albracht-Schulte et al., 2018). Other metabolites, such as endocannabinoids, are also derived from EPA and DHA (D’Angelo et al., 2020).

3 Physical activity and sport

During exercise, muscles are solicited in different ways depending on the discipline practiced. In particular, some disciplines require muscle mass gain such as weight lifting and throwing sports.

Several studies have shown that omega-3 fatty acids have anabolic effects (Jeromson et al., 2015) by increasing muscle protein synthesis through the activation of mTOR (Gammone et al., 2018) or p70s6k and mTOR (Albracht-Schulte et al., 2018; Jeromson et al., 2015). The benefits are all the more ostensible when an inflammatory state exists, for example during recovery from intense physical exercise such as eccentric contraction exercises, thanks to the restoration of the Akt/mTOR/FoxO3 signalling pathway (Jannas-Vela et al., 2023). However, while some studies have concluded an increase in muscle mass (Gammone et al., 2018), other did not found that increased muscle protein synthesis resulted in net muscle gain (Albracht-Schulte et al., 2018).

In addition, omega-3 fatty acids may reduce protein catabolism (Jeromson et al., 2015). Anti-inflammatory action is a main property of omega 3 fatty acids, thus they prevent protein degradation due to inflammation (Gammone et al., 2018). EPA supplementation has been shown to inhibit the transcription factor NF-kappa B, involved in the regulation of immunity and inflammation, and notably in the increase in protein degradation in inflammatory states (Jeromson et al., 2015) and it down-regulates proteasome expression involved in protein degradation (Huang et al., 2020). In addition, omega-3 fatty acids decrease circulating level of cortisol, a known activator of protein catabolism (Albracht-Schulte et al., 2018).

Exercise induced muscle damages, resulting in transient muscle inflammation, strength loss, muscle soreness and may cause subsequent exercise avoidance (Clarkson et al., 2002). Omega-3 fatty acids have been shown to be beneficial for muscle recovery, both in vitro and in animals or humans (Jannas-Vela et al., 2023). In fact, by contributing to the resolution of inflammation, omega-3 fatty acids enable faster healing of muscle lesions (Jannas-Vela et al., 2023). Feelings of fatigue and soreness could also be reduced by a high efficiency of the repair process with a reduction in markers of muscle damage (Gammone et al., 2018).

It is likely that the beneficial effects of omega-3 fatty acids arise from their incorporation into cell membranes (Macartney et al., 2019), as omega-3 fatty acids in phospholipid form have better bioavailability for metabolic pathways than in triglyceride form (Jeromson et al., 2015). Indeed, EPA and DHA from cell membranes can be better extracted for metabolism, like omega-6 fatty acids (Jannas-Vela et al., 2023). In rats, DHA is predominantly incorporated into the cell membranes of fast-type muscle fibers, and muscle fibers with a more oxygen-poor environment (Macartney et al., 2019). Thus integrated into cell membranes, omega-3 fatty acids contribute to membrane fluidity, promoting endocytosis and exocytosis. They also alter lipid rafts which can modify their function and activity, interfering with ion channels to regulate their activity (Kalupahana et al., 2020).

In addition, omega-3 fatty acids also improve muscle strength (Huang et al., 2020; Gammone et al., 2018). DHA participates in better conduction of action potentials, which improves the number of motor units recruited for a movement and therefore the force deployed (Gammone et al., 2018).

Systematic review and meta-analysis of the literature have led to the conclusion that an effect of omega 3 FA on muscle mass and strength exist (Abdelhamid et al., 2019; Rondanelli et al., 2021; Bird et al., 2021). However, it seems that the strength of the studies is rather low and that high quality randomized controlled trial are still required to validate the conclusions (Abdelhamid et al., 2019; Bird et al., 2021).

The actions of omega-3 fatty acids on mitochondria have also been reported. Notably, EPA promotes mitochondrial biogenesis (Kalupahana et al., 2020). Furthermore, EPA protects mitochondrial proteins while DHA induces an increase in mitochondrial mass, and the two influence mitochondrial fusion both in vitro and in vivo (Chen et al., 2018). In rats, fish oil rich in EPA and DHA increases mitochondrial fusion and reduces fission (Chen et al., 2018). DHA may even reverse the negative effects of palmitate, a saturated fatty acid, on mitochondrial fragmentation (Macartney et al., 2019). Thus omega-3 fatty acids increase mitochondrial synthesis (Albracht-Schulte et al., 2018) by increasing mRNA transcription (Jeromson et al., 2015).

In addition, omega-3 fatty acids promote lipid beta-oxidation in mitochondria, probably through activation of PPARα (Albracht-Schulte et al., 2018). Similarly, EPA and DHA, by activating AMPK, increase lipid oxidation (D’Angelo et al., 2020). EPA is catabolized more often than DHA (D’Angelo et al., 2020).

In summary, numerous studies show that omega-3 fatty acids increase protein anabolism and reduce protein catabolism in the context of exercise-related muscle damages. They could also increase muscular strength by acting on the nervous system and induce beneficial mitochondrial modifications.

4 Obesity

Obesity greatly increases the risk of developing various metabolic and cardiovascular pathologies, such as type 2 diabetes, atherosclerosis and high blood pressure. Weight loss is often difficult, and weight is easily regained later, because most obese individuals have little muscle mass, which is largely responsible for basal energy expenditure, while fat mass consumes little energy (Axelrod et al., 2023). Thus, the benefit of gaining muscle mass would be to increase basal metabolism, enabling longer-lasting weight loss.

Animal studies show that omega-3 fatty acids supplementation improves weight loss, insulin sensitivity and the resolution of inflammation (Kalupahana et al., 2020). However, these effects are not consistent in human studies (Kalupahana et al., 2020). Thus, some studies observe in humans, with omega-3 fatty acids supplementation, a significant increase in muscle mass gain, but the majority see no effect on muscle mass (Albracht-Schulte et al., 2018), or on weight loss (Kalupahana et al., 2020).

On the other hand, while omega-3 fatty acids do not significantly influence weight loss, they do potentiate the effects of a restrictive diet, even at low doses (Albracht-Schulte et al., 2018). What’s more, omega-3 fatty acids could help maintain weight loss (Kalupahana et al., 2020). Indeed, weight gain following weight loss is often due to a drop in leptin levels leading to increased hunger, yet EPA regulates leptin levels, helping to stabilize hunger and weight (Kalupahana et al., 2020). In mice, adequate omega-3 intakes during pregnancy and the first months of life appear to prevent obesity through the absence of adipocyte hypertrophy (Kalupahana et al., 2020). In humans, adequate omega-3 fatty acids intakes during pregnancy and the first months of life reduce the percentage of fat mass in childhood (Kalupahana et al., 2020).

Omega-3 fatty acids are also thought to have beneficial effects against the metabolic disorders associated with obesity. For example, they can improve insulin sensitivity, fatty acids oxidation and glucose tolerance (Gammone et al., 2018; Pinel et al., 2015), by increasing the expression of the glucose transporters GLUT1 and GLUT4 (Jeromson et al., 2015). In addition, EPA improves glucose uptake by cells, independently of Akt, a protein kinase involved in the insulin signaling pathway (Jeromson et al., 2015). Regarding insulin sensitivity, omega-3 intakes are inversely correlated with insulin resistance (Kalupahana et al., 2020). However, they are not able to improve it when it is already established, only to partially reduce it in adipose tissue via their anti-inflammatory action (Kalupahana et al., 2020).

5 Sarcopenia

Sarcopenia is the loss of muscle mass that occurs naturally with age. Omega-3 fatty acids can slow the loss of muscle mass (Jeromson et al., 2015). Indeed, by resorbing inflammation (Gammone et al., 2018) or influencing proteasome expression (Huang et al., 2020), omega-3 fatty acids decrease protein catabolism (Deval et al., 2016). EPA and DHA are both responsible for these actions (Vega et al., 2021). At 2 g/day, omega-3 fatty acids show measured results on muscle mass gain for elderly populations, and the magnitude of the benefit increases with higher doses (Huang et al., 2020). Omega-3 fatty acids could prevent the onset of sarcopenia (Gammone et al., 2018) when provided over the long term (Vega et al., 2021). It has also been demonstrated that EPA and DHA could increase muscle protein synthesis and muscle function in older adults (Smith et al., 2011, 2015). However, these results are controversial, since a meta-analysis reports no benefit of omega-3 fatty acids on muscle mass (Cornish et al., 2022). It should be noted that the inflammatory status of the subject was not taken into account in the latter. In subjects without low-grade inflammation, omega-3 fatty acid supplementation may be useless.

However, the European Sarcopenia Working Group EGWSOP has redefined sarcopenia to include loss of muscle strength (Cruz-Jentoft et al., 2019). The actions of omega-3 fatty acids on muscle strength are not significant at 2 g/day (Huang et al., 2020). Nevertheless, omega-3 fatty acids potentiate strength training-related improvements in muscle strength, possibly by increasing muscle sensitivity to acetylcholine, the neurotransmitter of muscle contraction (Jeromson et al., 2015). They may also improve information conduction along axons (Cornish et al., 2022). This benefit is of particular interest since decreased motor unit recruitment generally precedes loss of muscle function (Jeromson et al., 2015). In addition, an omega-3 fatty acids deficiency affects synaptic plasticity (D’Angelo et al., 2020). Finally, at very high doses (>3 g/d), omega-3 fatty acids alone are sufficient to maintain muscle mass and strength (Jeromson et al., 2015).

Thus, in conditions of muscle atrophy during aging, omega-3 fatty acids manage to maintain muscle mass and function, the effect for which they are most effective (Jeromson et al., 2015; Deval et al., 2016).

6 Cachexia

Cancer cachexia is a complication of cancer, consisting of loss of both fat and lean body mass associated with loss of appetite (Jin et al., 2022), in the presence of an inflammatory syndrome (Braha et al., 2022). Conclusions on the effects of omega-3 fatty acids on cancer cachexia are limited and controversial, but suggest that anti-inflammatory, anti-catabolic and anti-lipolytic properties are beneficial in the treatment of cancer cachexia (Freitas and Campos, 2019).

Half of clinical studies conclude that omega-3 fatty acids do not improve patients’ weight or muscle mass (Freitas and Campos, 2019; Braha et al., 2022; Jin et al., 2022). Omega-3 fatty acids nevertheless show benefits in terms of quality of life and patient survival (Jin et al., 2022; Freitas and Campos, 2019).

The other half of studies show that omega-3 fatty acids are able to halt weight loss (Jin et al., 2022), or even allow weight regain (Braha et al., 2022). Omega-3 fatty acids combined in different supplements also produce positive results on weight gain, although it is not possible to determine how much is due to omega-3 fatty acids and how much to other components (Mochamat et al., 2016). Finally, omega-3 fatty acids enable greater weight gain than a placebo, demonstrating their validity in the treatment of cachexia, albeit less effectively than conventional megestrol acetate treatment (Harvie, 2014).

The beneficial effects of omega-3 fatty acids are explained by several mechanisms. Firstly, reduced systemic inflammation decreases inflammation-induced protein catabolism (Jin et al., 2022). EPA also acts by decreasing protein degradation (Braha et al., 2022), thus inhibiting the muscle atrophy of cachexia (Harvie, 2014). EPA also inhibits ubiquitin signaling of proteasomes, reducing protein degradation (Jeromson et al., 2015).

Lastly, an effect of omega-3 fatty acids that is ancillary to muscle but important in the treatment of cancer cachexia is the reduction of medical anorexia (Vega et al., 2021).

The hypotheses put forward to explain the lack of action of omega-3 fatty acids in half the studies is the fact that significant weight loss in cachexia is largely due to loss of appetite; thus, energy intakes remain low despite high requirements (Jin et al., 2022). However, omega-3 supplementation provides a few grams of lipids which, although calorific, do not restore the balance between intake and expenditure (Jin et al., 2022). The effects of omega-3 fatty acids would therefore be existing but insufficient to be detected clinically, or to significantly improve patients (Jin et al., 2022). Recently, it has been found that DHA could prevent cancer cell escape from immune surveillance and be a tool in the prevention of malignancy (Zhang et al., 2023) and the development of cachexia.

For these reasons, in 2017, the European Society for Clinical Nutrition and Metabolism (ESPEN) included omega-3 fatty acids in the treatment recommendations for cancer cachexia (Freitas and Campos, 2019). However, omega-3 fatty acids supplementation is thought to be more effective if started at the pre-cachectic stage, in order to protect muscles from excessive catabolism without being hampered by the imbalance in energy balance (Jin et al., 2022).

7 Conclusion

Compendiously, in addition to their well-known anti-inflammatory and cardiovascular health properties, omega-3 fatty acids could prevent muscle catabolism and increase anabolism. In this sense, they are useful for athletes to combat the resistance to anabolism that can appear and hinder muscle mass gain, but also for the elderly in prevention and as a complement to treatment for sarcopenia, as well as for patients at risk of cancer cachexia to protect their muscle mass. With regard to obesity, the effects of omega-3 fatty acids are also beneficial directly on muscle mass gain or indirectly by reducing insulin resistance.

The multiple beneficial effects on skeletal muscle described in this review can be achieved with a diet that provides omega-3 fatty acids (fish and shellfish) and directly with dietary supplementation. In France, the foods that contribute to omega-3 fatty acids intake are rapeseed oil, walnuts and walnut oil, and fish, shellfish and crustaceans, but only seafood provides EPA and DHA. Yet global warming could reduce the omega-3 content of algae, affecting the entire marine food chain (Jeromson et al., 2015). What’s more, at their current rate of exploitation, fishery resources are dwindling. This is why various species of algae, krill, plankton but also sponges, fungi and bacteria are currently being studied as alternative sources of EPA and DHA, with the aim of being widely exploited and commercialized (Gammone et al., 2018). Thus, the challenge for the coming years is to develop and secure sustainable sources of omega 3 for the future.

Conflicts of interest

The authors declare no competing interest.

Author contribution statement

All the authors wrote the paper and approved the final version of this manuscript.


  • Abdelhamid A, Hooper L, Sivakaran R, Hayhoe RPG, 2019. Welch A; PUFAH Group. The relationship between omega-3, omega-6 and total polyunsaturated fat and musculoskeletal health and functional status in adults: a systematic review and meta-analysis of RCTs. Calcif Tissue Int 105: 353–372. [CrossRef] [PubMed] [Google Scholar]
  • Albracht-Schulte K, Kalupahana NS, Ramalingam L, Wang S, Rahman SM, Robert-McComb J, Moustaid-Moussa N. 2018. Omega-3 fatty acids in obesity and metabolic syndrome: a mechanistic update. J Nutr Biochem 58: 1–16. [Google Scholar]
  • ANSES. 2016. Actualisation des repères du PNNS : révision des repères de consommations alimentaires. Maisons-Alfort: Anses. [Google Scholar]
  • Axelrod CL, Dantas WS, Kirwan JP. Metabolism. 2023. Sarcopenic obesity: emerging mechanisms and therapeutic potential. Metabolism 146: 155639. [CrossRef] [PubMed] [Google Scholar]
  • Bird JK, Troesch B, Warnke I, Calder PC. 2021 The effect of long chain omega-3 polyunsaturated fatty acids on muscle mass and function in sarcopenia: a scoping systematic review and meta-analysis. Clin Nutr ESPEN 46: 73–86. [CrossRef] [PubMed] [Google Scholar]
  • Braha A, Albai A, Timar B, Negru Ș, Sorin S, Roman D, Popovici D. 2022. Nutritional interventions to improve cachexia outcomes in cancer—a systematic review. Medicina (Kaunas) 21;58: 966. [CrossRef] [PubMed] [Google Scholar]
  • Brenna JT. 2002. Efficiency of conversion of alpha-linolenic acid to long chain n-3 fatty acids in man. Curr Opin Clin Nutr Metab Care 5: 127–132. [CrossRef] [PubMed] [Google Scholar]
  • Chen PB, Yang JS, Park Y. 2018. Adaptations of skeletal muscle mitochondria to obesity, exercise, and polyunsaturated fatty acids. Lipids 53: 271–278. [Google Scholar]
  • Clarkson PM, Hubal MJ. 2002. Exercise-induced muscle damage in humans. Am J Phys Med Rehabil 81: S52– S69. [CrossRef] [PubMed] [Google Scholar]
  • Cornish SM, Cordingley DM, Shaw KA, Forbes SC, Leonhardt T, Bristol A, Candow DG, Chilibeck PD. 2022. Effects of omega-3 supplementation alone and combined with resistance exercise on skeletal muscle in older adults: a systematic review and meta-analysis. Nutrients 14: 2221. [CrossRef] [PubMed] [Google Scholar]
  • Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyère O, Cederholm T, Cooper C, Landi F, Rolland Y, Sayer AA, Schneider SM, Sieber CC, Topinkova E, Vandewoude M, Visser M, Zamboni M; Writing Group for the European Working Group on Sarcopenia in Older People 2 (EWGSOP2), and the Extended Group for EWGS OP2. 2019. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing 48: 16–31. [Google Scholar]
  • D’Angelo S, Motti ML, Meccariello R. 2020. Omega-3 and omega-6 polyunsaturated fatty acids, obesity and cancer. Nutrients 12: 2751. [CrossRef] [PubMed] [Google Scholar]
  • Deval C, Capel F, Laillet B, Polge C, Bechet D, Taillandier D, Attaix D, Combaret L. 2016. Docosahexaenoic acid-supplementation prior to fasting prevents muscle atrophy in mice. J Cachexia Sarcopenia Muscle 7: 587–603. [CrossRef] [PubMed] [Google Scholar]
  • Freitas RD, Campos MM. 2019. Protective effects of omega-3 fatty acids in cancer-related complications. Nutrients 11: 945. [CrossRef] [PubMed] [Google Scholar]
  • Gammone MA, Riccioni G, Parrinello G, D’Orazio N. 2018. Omega-3 polyunsaturated fatty acids: benefits and endpoints in sport. Nutrients 11: 46. [CrossRef] [PubMed] [Google Scholar]
  • Harvie M. 2014. Nutritional supplements and cancer: potential benefits and proven harms. Am Soc Clin Oncol Educ Book e478–86. [CrossRef] [PubMed] [Google Scholar]
  • Huang YH, Chiu WC, Hsu YP, Lo YL, Wang YH. 2020. Effects of omega-3 fatty acids on muscle mass, muscle strength and muscle performance among the elderly: a meta-analysis. Nutrients 12: 3739. [CrossRef] [PubMed] [Google Scholar]
  • Jannas-Vela S, Espinosa A, Candia AA, Flores-Opazo M, Peñailillo L, Valenzuela R. 2023. The role of omega-3 polyunsaturated fatty acids and their lipid mediators on skeletal muscle regeneration: a narrative review. Nutrients 15: 871. [CrossRef] [PubMed] [Google Scholar]
  • Jeromson S, Gallagher IJ, Galloway SD, Hamilton DL. 2015. Omega-3 fatty acids and skeletal muscle health. Mar Drugs 13: 6977–7004. [Google Scholar]
  • Jin X, Xu XT, Tian MX, Dai, Z. 2022. Omega-3 polyunsaterated fatty acids improve quality of life and survival, but not body weight in cancer cachexia: a systematic review and meta-analysis of controlled trials. Nutr Res 107: 165–178. [CrossRef] [PubMed] [Google Scholar]
  • Kalupahana NS, Goonapienuwala BL, Moustaid-Moussa N. 2020. Omega-3 fatty acids and adipose tissue: inflammation and browning. Annu Rev Nutr 40: 25–49. [CrossRef] [PubMed] [Google Scholar]
  • Macartney M, Peoples G, Treweek T, McLennan P. 2019. Docosahexaenoic acid varies in rat skeletal muscle membranes according to fibre type and provision of dietary fish oil. Prostaglandins Leukot Essent Fatty Acids 151: 37–44. [Google Scholar]
  • Mochamat CH, Marinova M, Kaasa S, Stieber C, Conrad R, Radbruch L, Mücke M. 2016. A systematic review on the role of vitamins, minerals, proteins, and other supplements for the treatment of cachexia in cancer: a European Palliative Care Research Centre cachexia project. J Cachexia Sarcopenia Muscle 8: 25–39. [Google Scholar]
  • Pinel A, Rigaudiere JP, Laillet B, Pouyet C, Malpuech-Brugere C, Prip-Buus C, Morio B; Capel F. 2015. N-3PUFA differentially modulate palmitate-induced lipotoxicity through alterations of its metabolism in C2C12 muscle cells. Biochim Biophys Acta 1861: 12–20. [Google Scholar]
  • Rondanelli M, Perna S, Riva A, Petrangolini G, Di Paolo E, Gasparri C. 2021. Effects of n-3 EPA and DHA supplementation on fat free mass and physical performance in elderly. A systematic review and meta-analysis of randomized clinical trial. Mech Ageing Dev 196: 111476. [Google Scholar]
  • Smith GI, Atherton P, Reeds DN, Mohammed BS, Rankin D, Rennie MJ, Mittendorfer B. 2011. Dietary omega-3 fatty acid supplementation increases the rate of muscle protein synthesis in older adults: a randomized controlled trial. Am J Clin Nutr 93: 402–412. [CrossRef] [PubMed] [Google Scholar]
  • Smith GI, Julliand S, Reeds DN, Sinacore DR, Klein S, Mittendorfer B. 2015. Fish oil-derived n-3 PUFA therapy increases muscle mass and function in healthy older adults. Am J Clin Nutr 102: 115–122. [CrossRef] [PubMed] [Google Scholar]
  • Valenzuela R, Metherel AH, Cisbani G, Smith ME, Chouinard-Watkins R, Klievik BJ, Videla LA, Bazinet RP. 2024. Protein concentrations and activities of fatty acid desaturase and elongase enzymes in liver, brain, testicle, and kidney from mice: Substrate dependency. Biofactors 50: 89–100. [CrossRef] [PubMed] [Google Scholar]
  • Vega OM, Abkenari S, Tong Z, Tedman A, Huerta-Yepez S. 2021. Omega-3 polyunsaturated fatty acids and lung cancer: nutrition or pharmacology? Nutr Cancer 73: 541–561. [Google Scholar]
  • Videla LA, Hernandez-Rodas MC, Metherel AH, Valenzuela R. 2022. Influence of the nutritional status and oxidative stress in the desaturation and elongation of n-3 and n-6 polyunsaturated fatty acids: impact on non-alcoholic fatty liver disease. Prostaglandins Leukot Essent Fatty Acids 181: 102441. [Google Scholar]
  • Zhang H, Chen H, Yin S, Fan L, Jin C, Zhao C, Hu H. 2023. Docosahexaenoic acid reverses PD-L1-mediated immune suppression by accelerating its ubiquitin-proteasome degradation. J Nutr Biochem 112: 109186. [Google Scholar]

Cite this article as: Doussat C, Brioche T, Casas F, Capel F, Feillet-Coudray C. 2024. Dietary omega 3 fatty acids and skeletal muscle metabolism: a review of clinical and preclinical studies. OCL, 31: 13

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