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Degradation profile of leuprolide in NLC LEU (fx1), NLC HIP (fx2), SLN LEU (fx3) and SLN HIP (fx4) by trypsin and α-chymotrypsin compared to free LEU (fx5) in Tris-HCl pH 6.8 buffered medium (mean ± SEM, n = 3, *p < 0.05 and **p < 0.01). Reprinted from Dumont et al. (2019a) with permission from Elsevier.
NLC: nanostructured lipid carriers; LEU: leuprolide; HIP: hydrophobic ion pair; SLN: solid lipid nanoparticles.
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