Figure 1


Download original image

High-fat high-calorie-fed wild-type mice exhibit a gut microbiota dysbiosis and an increased permeability of the intestinal epithelium partly due to a lowered expression of the tight junction proteins but also to a decrease of the integrity of the mucus layer in relation to endoplasmic reticulum stress. This intestinal hyperpermeability facilitates the crossing of LPS leading to low-grade inflammation observed in obese individual. Conversely, we evidenced that fat-1 mice are protected against dysbiosis and intestinal hyperpermeability by a higher expression of tight junction proteins and an unaltered colonic mucus layer, which might be explained at least by the fact that a prevention of the reticulum stress and a higher proportion of Akkermansia muciniphila were observed in fat-1 mice which display a lean phenotype. In addition, the ceacal microbiome transplantation of fat-1 mice to wild-type mice totally prevented high-fat-induced alteration of the colonic mucus layer and endoplasmic reticulum stress in colonic tissues. FFA: free fatty acids; HF/HS: high fat/high sucrose; LPS: lipopolysaccharides; MUC2: mucin 2; OCLN: occludine; ER: endoplasmic reticulum; UPR: unfolded protein response; WT: wild-type; ZO-1: zonula occludens-1.

Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.

Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.

Initial download of the metrics may take a while.