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Major pathways of PUFA metabolization, from dietary fatty acids to major members of the oxylipin family, including the commons enzymatic hubs of metabolization between ω6 and ω3 PUFAs. COX: cyclooxygenase; LOX: lipoxygenase; HODEs: hydroxyoctadecadienoic acids; LA: linoleic acid; LNA: alpha-linolenic acid; ARA: arachidonic acid; EPA: eicosapentaenoic acid; DHA: docosahexaenoic acid. The number of carbon atoms is indicated.
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