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Effects of artificial increase of cholesterol at the cellular plasma membrane.

In the control condition, APP and BACE1 are present inside and outside lipid rafts at the plasma membrane. Raising cholesterol at the plasma membrane induces: i) relocalization of APP and BACE1 in lipid rafts and their rapid internalization assessed by Fluorescence correlation Spectroscopy in enlarged and clustered endosomes (Marquer et al., 2011; Marquer et al., 2014); ii) increase of APP and BACE1 proximity assessed by Total Internal Reflection Fluorescence-Fluorescence Lifetime Imaging-Förster Resonance Energy Transfer (TIRF-FLIM-FRET) microscopy (Marquer et al., 2011); iii) increase of production of Aβ peptides (Cossec et al., 2010a; Cossec et al., 2010b; Marquer et al., 2014).

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