Table 2

Experimental features and main data of the previous studies on the role of arachidonic acid in AD. We previously showed the mice in which the expression of the main ARA releasing enzyme cPLA₂ has been suppressed, are resistant to the neurotoxicity of the Aβ peptide oligomers. By contrast, an ARA-rich diet increase the sensitivity of the mice to the neurotoxicity of the Aβ peptide oligomers. Two other teams studied the role of dietary ARA and reported conflicting results.

Sources	Main experimental features	Main experimental data
Desbène et al., 2012	cPLA2−/− mice ICV injection of Aβ peptides	→ cognitive abilities in cPLA2−/− mice → PSD95 and SNP25 in cPLA2−/− mice
Thomas et al., 2017	Balb/c mice 1% ARA diet for 12 weeks ICV injection of Aβ peptides	Learning abilities AMPA Receptors GFAP
Amtul et al., 2012	CRND8 mice 2% ARA diet for 21 weeks	Aβ1–42 production and deposition
Hosono et al., 2015a, 2015b	Tg2576 mice ARA Supplementation of the diet 4%	Cognitive alteration Amyloid plaques