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Table 2

Experimental features and main data of the previous studies on the role of arachidonic acid in AD. We previously showed the mice in which the expression of the main ARA releasing enzyme cPLA2 has been suppressed, are resistant to the neurotoxicity of the Aβ peptide oligomers. By contrast, an ARA-rich diet increase the sensitivity of the mice to the neurotoxicity of the Aβ peptide oligomers. Two other teams studied the role of dietary ARA and reported conflicting results.

Sources Main experimental features Main experimental data
Desbène et al., 2012 cPLA2−/− mice
ICV injection of Aβ peptides
→ cognitive abilities in cPLA2−/− mice
→ PSD95 and SNP25 in cPLA2−/− mice
Thomas et al., 2017 Balb/c mice
1% ARA diet for 12 weeks
ICV injection of Aβ peptides
Learning abilities
AMPA Receptors
Amtul et al., 2012 CRND8 mice
2% ARA diet for 21 weeks
1–42 production and deposition
Hosono et al., 2015a, 2015b Tg2576 mice
ARA Supplementation of the diet 4%
Cognitive alteration
Amyloid plaques

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