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The mechanism of niacin-induced skin flushing (adapted from Messamore et al., 2010). Abbreviations: COX, cyclooxygenase; PLA2, phospholipase A2; IL, interleukin; INF, interferon; TNF, tumor necrosis factor; PGD2, prostaglandin D2; PGF2 prostaglandin F2.
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