Long life adequate diet consumption does not protect from age-associated neuroinflammation. After mating, female mice were submitted either to an essential fatty acid adequate diet containing a mixture of rapeseed oil (rich in α-LNA), high-oleic sunflower oil and palm oil resulting in an α-LNA/LA ratio of ¹/₄ (n-3 adequate diet), or to n-3 PUFA deficient diet (n-3 deficient diet) containing only sunflower oil. Male pups were fed the same diets as their dams. IL-6 and IL-10 were measured by multiplex in the cortex of adult (3-5 month-old) and aged (19-23 month-old) mice fed the n-3 adequate (diet or n-3 deficient diet. Data are expressed as mean ± SEM. Age effect, ***p<0.001. (Moranis et al., 2011)