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Omega-3 α-linolenic acid increases neurogenesis and synaptogenesis. A) Three and 21 days after the subchronic ALA-treatment, cell proliferation is increased in the Dentate Gyrus (left panel). The proliferating cells are immature neurons identified 3 days after the last ALA injection and mature neurons 21 days later. B) ALA treatment increases the levels of different markers of synaptogenesis in cortex, hippocampus at Day 10. Highlighted in the box is immunostaining for SNAP-25, a synaptosome-associated exocytosis protein, in the cortex of ALA500-treated animals at Day 10 showing the increased in synaptogenesis by ALA treatment.
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