Effects of Omega-6 and Omega-3 Fatty Acids on Telomere Length.
|Telomeres are tandem repeat DNA sequences (TTAGGG)n that form a protective cap at the ends of eukaryotic chromosomes|
|During somatic cell division, DNA polymerase cannot fully replicate the 3’ end of linear DNA, resulting in an obligate and progressive loss of telomeric repeats. This process may eventually result in cellular senescence or apoptosis|
|Telomere length is emerging as a novel marker of biological age which integrates the cumulative life time burden of genetic factors and environmental stressors independent of chronological age|
|A strong association between short telomeres and cardiovascular morbidity and mortality has been documented in several populations|
|Increased dietary intake of marine omega-3 fatty acids is associated with prolonged survival in patients with Coronary Heart Disease|
|Telomeres may lengthen as well as shorten|
|In a cohort of patients with coronary artery disease, there was an inverse relationship between baseline blood levels of marine omega-3 fatty acids and the rate of telomere shortening over 5 years|
|Leukocyte telomere length is associated with diseases of aging and is a potential biomarker of chronic disease risk|
|Linoleic acid intake is inversely associated with leukocyte telomere length after multivariate adjustment in women|
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