Effects of Omega-3 Fatty Acids on Factors Involved in the Pathophysiology of Atherosclerosis and Inflammation.
|Effect of w-3 fatty acid
|Eicosanoid precursor, aggregates platelets; stimulates white blooo cells
|Platelet aggregation; vasoconstriction; increase of intracellular Ca++
|Prevent platelet aggregation; vasodilation; increase cAMP
|Neutrophil chemattractant; increase of intracellular Ca++
|A member of the acute phase response; and a blood clotting factor
|Tissue pasminogen activator
|Increase endogenous fibrinolysis
|Platelet activating factor (PAF)
|Activates platelets and white blood cells
|Platelet-derived growth factor (PDGF)
|Chemoattractant and mitogen for smooth muscles and macrophages
|Oxygen free radicals
|Cellular damage; enhance LDL uptake via scavenger pathway; stimulate arachidonic acid metabolism
|Stimulate eicosanoid formation
|Interleukin 1 and tumor necrosis factor
|Stimulate neutrophil O2 free radical formation; stimulate lymphocyte proliferation; stimulate PAF; express intercellular adhesion molecule-1 on endothelial cells; inhibit plasminogen activator, thus, procoagulants
|Stimulates the synthesis of all acute phase proteins involved in the inflammatory response: C-reactive protein; serum amyloid A:, fibrinogen; α1-chymotrypsin; and haptoglobin
|C-reactive protein (CRP)
|An acute phase reactant and an independent risk factor for cardiovascular disease
|Endothelial-derived relaxation factor
|Reduces arterial vasoconstrictor response
|Increases sensitivity to insulin
|Related to LDL and HDL level
|Decreases the risk for coronary heart disease
|Lipoprotein(a) is a genetically determined protein that has atherogenic and thrombogenic properties
|Triglycerides and chylomicrons
|Contribute to postprandial lipemia
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