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Table 4.

Effects of ingestion of EPA and DHA from fish or fish oil.

Decreased production of prostaglandin E2 (PGE2) metabolites
A decrease in thromboxane A2, a potent platelet aggregator and vasoconstrictor
A decrease in leukotriene B4 formation, an inducer of inflammation, and a powerful inducer of leukocyte chemotaxis and adherence
An increase in thromboxane A3, a weak platelet aggregator and weak vasoconstrictor
An increase in prostacyclin PGI3, leading to an overall increase in total prostacyclin by increasing PGI3 without a decrease in PGI2, both PGI2 and PGI3 are active vasodilators and inhibitors of platelet aggregation
An increase in leukotriene B5, a weak inducer of inflammation and a weak chemotactic agent

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