Volume 18, Number 5, Septembre-Octobre 2011Lipids and Brain II. Actes des Journées Chevreul 2011 (Deuxième partie)
|Page(s)||237 - 241|
|Section||Signalling Mechanisms and Metabolism of Omega-3 PUFA in the Brain|
|Published online||15 September 2011|
Docosahexaenoic acid: membrane modification and neurotrophic mechanisms
Laboratory of Molecular Signaling, DICBR, NIAAA, NIH, 5625 Fishers Lane, Bethesda, MD 20892-9410
Docosahexaenoic acid (DHA, 22:6n-3) is highly enriched in the brain mainly in membrane phospholipids. Maintenance of a high DHA concentration in brain is essential for proper neuronal function, suggesting a unique requirement of this fatty acid for an optimal membrane structure and function in the nervous system. This article discusses mechanisms supporting neurotrophic function of DHA, particularly the role of DHA in membrane modification and related cell signaling leading to neuronal survival and differentiation.
Key words: docosahexaenoic acid / neuronal cells / phosphatidylserine / apoptosis / survival / neurite growth / synaptamide / synaptogenesis / synaptic function / Akt / Raf-1 / membrane
© John Libbey Eurotext 2011
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