Volume 14, Number 2, Mars-Avril 2007
|Page(s)||110 - 115|
|Published online||15 March 2007|
GC-MS analysis of allergens in plant oils meant to cosmetics
Laboratoire de chimie analytique (Faculté de pharmacie) et UMR mixte Aix-Marseille 2 – INSERM 476 – INRA 1260 (Faculté de Médecine), Université de la Méditerranée, 27 Boulevard Jean Moulin, 13385
Marseille Cedex 5, France
2 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta 31527, Egypt
Accepted: 20 December 2006
Cutaneous allergy occurs mainly as a result of the use of domestic products and cosmetics. Some fragrances, present in these products, may contain compounds that are responsible for allergy (allergens). The European Council offered a Directive limiting the level of 26 allergens found in cosmetics. GC-MS technique was used to determine the retention times of 25 allergens, determine detection and quantification limits and make calibration with standard solution of each allergen in concentrations ranging from 10 to 200 mgL–1 (21 allergens) and 50 to 200 mgL–1 (4 allergens). Quantification was performed by the use of 2 internal standards (tetradecane and hexadecane). Seven oils issued from plants were studied by GC-MS. For all of them, the concentration of potential allergens was lower than their minimum detectable level. The alcoholic solution of extracts issued from different samples of oil did not demonstrate the presence of any quantifiable allergen, even when was concentrated 25 times. GC-MS could be a useful technique in the identification and, if necessary, quantification of allergen in ingredients meant to cosmetics.
Key words: GC-MS / allergens / ingredients meant to cosmetics / plant oils / European Council Directive
© John Libbey Eurotext 2007
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.