Volume 13, Number 1, Janvier-Février 2006
|Page(s)||70 - 75|
|Published online||15 January 2006|
Effet d’un régime riche en acides gras ω3 et en CLA 9-cis, 11-trans sur l’insulinorésistance et les paramètres du diabète de type 2
Centre d’enseignement et de recherche en nutrition, Centre hospitalier de Bretagne Sud, 56322
2 Valorex, Combourtillé, 35210 France
3 Laboratoire de biochimie, Ensa/Inra, Rennes, 35000 France
Accepté : 11 Janvier 2006
The prevalence of type 2 diabetes, a pathology mainly induced by nutrition is increasing. In vivo studies on rat have demonstrated the interest of n-3 long chains polyunsaturated fatty acids (n-3 LC PUFA) and conjugated linoleic acids (CLA) in the diet to improve insulin sensibility. This study investigates the effect of a diet with products (linseed enriched livestock diet products and linseed bread) naturally enriched in n-3 PUFA and CLA 9-cis, 11-trans on glycemic parameters of type 2 diabetics. 44 type 2 diabetics were randomised in three parallel groups and followed a particular diet during 100 days. The three diets: diet A (n = 13), enriched in n-3 PUFA via bread, eggs and pastas, diet B (n = 13), enriched in n-3 PUFA and richer in conjugated linoleic acids (CLA) via bread, eggs, pastas, beef meat and dairy products and diet T (n = 18), standard, were otherwise similar in energy (1970 kcal per day) and type of food. The serum value of the ALA is significantly higher for group A and B and the CLA serum value is significantly higher for the group B only at the end of the study. At the end of the study, fasting insulinemia is lower in group B compared with group A (p = 0,06) and T (p < 0,05) while glycemia does not differ between groups. Insulin resistance is also lower in group B compared with groups A and T, but the differences do not reach significance (p = 0,08 and p = 0,1 respectively). These results suggest the potential implication of CLA 9-cis, 11-trans in a diet rich in ALA in the improvement of insulin sensitivity.
Key words: type 2 diabetes / nutrition / conjugated linoleic acids
© John Libbey Eurotext 2006
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.