Effets des acides gras conjugués sur les composantes de la dépense énergétique chez la souris et le hamster

¹ UMR INRA/INA P-G 914, Physiologie de la nutrition et du comportement alimentaire, 16, rue Claude Bernard, 75231 Paris Cedex 05
² Laboratoire de physiologie de la nutrition, Université Paris-Sud, Bat. 447, campus d’Orsay, 91405 Orsay Cedex
³ Inserm U465, Institut Biomédical des Cordeliers, 15, rue de l’Ecole de Médecine, 75270 Paris Cedex 06

Abstract

We measured the effects of feeding conjugated linoleic acids (CLA) on the various components of energy expenditure in two species known to react differently to CLA treatments, the hamster and the mouse. We measured in particular resting energy expenditure, and the metabolic responses to feeding and treadmill exercise. Our results confirmed the poor responsivenes of hamsters and the high sensibility of mice. In agreement with the lack of effects of CLAs on body weight and body composition in hamsters, we did not find any significant effects on the various components of energy expenditure. Mice responded to CLA feeding by a complete inhibition in the development of the white adipose tissue, but we observed only marginal effects of the components of energy expenditure, and it was difficult to separate the metabolic alterations that resulted from the energy deficit and those that could be specifically attributed to CLAs feeding. However, the possibility that a high spontaneous activity together with the progressive development of a form of insulin resistance participate in the lipoatrophy observed in mice.