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(a) The fasting serum total cholesterol level of the mice from week 0 to week 8; (b) A comparison between fecal bile acid of the mice before (week 0) and after (week 8) the gavage. The data label at the base of each bar represents fold expression relative to the respective week 0 reading (which is arbitrarily set as 1.00-fold); (c) The expression of bile metabolic genes found in C57BL/6 mice liver tissue following the gavage experiment. Note: * representing significance above CM protein level in (d) is missing; (d) The representative Western blot image of Fxr and Actb proteins in mice liver tissue. The mRNA (C) and protein (D) expression levels were determined by normalization to Actb expression and relative to WC (1.00-fold). WC: water control group (n = 6); CM: coconut milk group (n = 8); and CR: light cream group (n = 6). Two-tailed paired sample t-test (solid line) and one-way ANOVA Tukey’s test (dotted line) were performed on the result. *p < 0.05 and **p < 0.01 signifies a statistically significant alteration from WC control; ##p < 0.01 signifies statistical significant change from week 0 control; while NS represents non-significance.
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