Ceramides metabolism and impaired epidermal barrier in cutaneous diseases and skin aging: focus on the role of the enzyme PNPLA1 in the synthesis of ω-O-acylceramides and its pathophysiological involvement in some forms of congenital ichthyoses | OCL

Lipids in the elderly: needs, nutrition and physiopathology / Les lipides pour les seniors : besoins, alimentation et physiopathologie

Open Access

Review

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Omega-O-acylceramide is an epidermis specific sphingolipid with a crucial role for epidermal barrier function.

Diagram showing the synthesis and transport of omega-O-acylceramide in the granular keratinocyte, their secretion at the interface stratum granulosum/stratum corneum and their extracellular processing and assembling into the stratum corneum lipid structures (lamellae and cornified lipid envelope) (see text for details).

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