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Experimental layout of Thomas et al. (2017) study. In this study, two groups groups of mice were fed for 12 weeks either with an oleic acid rich diet (control OLE diet) or an ARA-rich diet (ARA diet). The two diets contained similar amounts of saturated and ω-3 fatty acids. In the OLE diet, oleic acid replace the excess of ω-6 fatty acids (mainly ARA). At week 10, the two groups of mice were submitted to intracerebroventricular injections of Aβ(1-42) peptide oligomers or saline solution (control). Congitive abilities were measured by using the Y-maze (short term memory) and the Moorris Water maze (long term memory) tests. Mice were sacrificed at the end of week 12 and blood, liver and brain samples were collected for protein (synaptic proteins in brain) and lipid analyses.
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