Open Access

Table 1

Classification of biomarkers used in the differential diagnosis of AD. These markers are recommended by NIA-AA.

Biomarkers for AD Pathophysiological correlate
   Tests for episodic memory
/delayed recall
Hippocampal amnesia due to AD
Cerebrospinal fluid
   Aβ42 Neuronal Aβ plaque accumulation
   Total-tau Neuronal degeneration
   Phosphorylated tau Intra neuronal NFT
Amyloid Imaging
   Aβ PET Neuronal Aβ plaque accumulation
Structural neuroimaging
   Magnetic resonance imaging (MRI) Neuronal injury marker
   Computed tomography (CT) Neuronal injury marker
Functional neuroimaging
   FDG-PET Glucose hypometabolism

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