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Rod-mediated function deteriorated in VLC-PUFA–deficient mice. Representative 12-month-old WT (A) responses to increasing light intensities (–3.0 log scot cd·s/m2 to 3.0 log scot cd·s/m2) had higher a- and b-wave amplitudes than 9-month-old KO (B) responses. Vertical bar at upper right in each case is y-axis amplitude = 200 μV. (C) WT oscillatory potentials (OPs) had amplitudes higher than the KO (D) OP amplitudes. Vertical bar at upper right in each case is y-axis amplitude = 20 μV. The numbers between the traces in (A, C) are the light intensities (log scot cd·s/m2) at which the responses were elicited. The latency of the OP responses was not different between the mice. (This research was originally published in Investigative Ophthalmology and Visual Science. Bennett et al. (2014). © Association for Research in Vision and Ophthalmology.)
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