Figure 2.
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Inflammation alters amino acid metabolism. Low-grade systemic inflammation in elderly (> 65 years-old) is associated with alterations in the activity of two enzymatic pathways, the indoleamine 2,3 dioxygenase (IDO) and guanosine-triphosphate-cyclohydrolase-1 (GTP-CH1) pathways, which are involved on in the metabolism of key monoamines serotonin and (Capuron et al., 2011).
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