Lipids Online 2022 : the role of elongase 2 on EPA and DHA metabolism (free webinar)

“The role of elongase 2 on eicosapentaenoic acid and docosahexaenoic acid metabolism” is the title of the coming ISSFAL’s seminar. This free webinar will be proposed the 13th of July 2022 (10:00 AM New York City | 15:00 London | 10:00 PM Singapore) by Adam Metherel, PhD (Department of Nutritional Sciences @University of Toronto, Canada

Increases in eicosapentaenoic acid (EPA, 20:5n-3) levels following docosahexaenoic acid (DHA, 22:6n-3) supplementation has long been explained by the retroconversion pathway. Conversely, a lack of increase in DHA levels following precursor supplementation, such as EPA, has been used as evidence for low DHA synthesis rates. However, recent evidence from animal and human modeling reveals that increases in EPA with DHA supplementation may be the result of an inhibition of EPA metabolism, and despite no changes in DHA levels with EPA supplementation, substantial synthesis of DHA occurs. New evidence indicates that inhibition of elongase 2 by DHA may explain the increased EPA levels – not retroconversion. Elongase 2 also appears to be an important regulatory enzyme for DHA synthesis, particularly as a mechanism to explain the well-known higher DHA levels in women compared with men. This presentation will review these findings and present new evidence highlighting the potentially important role of elongase 2 in EPA and DHA metabolism.

Free Webinar (ISSFAL’s members and non-members are invited)