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Effect of DHA-Alb after MCAo in aged rats. (a) Total behavioral score (normal score = 0, maximal score = 12) during MCAo (60 min) and on days 1, 2, 3 and 7 after treatment; (b) 3D reconstructions of MRI-derived lesion volumes from high resolution T2 weighted images; (c) computer-generated MosaiX processed images of Nissl stained paraffin-embedded brain sections; (d) total infarct volume. DHA-Alb treatment significantly improved neurological score, reduced MRI lesion volume and attenuated infarct size compared to the saline group during the 7-day survival period. Values shown are means ± SEM. #p< 0.05versus saline group; ∗p< 0.05 DHA-Alb versus Alb group (repeated measures ANOVA followed by Bonferroni tests).
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