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Figure 1.


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Evolution of the composition of Labrasol® (A) and Gelucire® 44/14 (B) during their gastrointestinal lipolysis by rDGL and PPE as a function of time. The vertical line at 30 min represents the end of gastric lipolysis step and the beginning of duodenal lipolysis step. The variations are expressed in percent of mono-, di-, and triacylglycerols (MAG, DAG, and TAG, respectively) and PEG mono- and diesters (MPEG and DPEG, respectively) initially present in the excipients. For free PEG, only the amount of free PEG released upon the lipolysis of PEG esters are shown and expressed in percent of the amounts of PEG initially present in the excipients. Adapted from Fernandez et al., 2009.

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